A novel sensor system of denture base type was developed for simultaneous monitoring of salivary pH and tissue temperature in the oral cavity. Fundamental components of the monitoring system, sensor devices and sensor configuration are showed in this paper. The sensor units consist of IrO2 electrode and thermistor circuit implanted in the denture base that is tightly fixed in the oral cavity. The signals are transmitted by PFM-FM telemeter system that can be used for health care of the aged people without restraint of their daily behavior while at work, sleeping and even at exercise. Some of results concerning the basic characteristics of the sensor system and continuously monitored physiological data were obtained from the preliminary experiments. Availability of the whole system and monitoring method was discussed.