A digital background calibration technique using signal-dependent dithering is proposed, to correct the nonlinear errors which results from capacitor mismatches and finite opamp gain in pipelined analog-to-digital converter (ADC). Large magnitude dithers are used to measure and correct both errors simultaneously in background. In the proposed calibration system, the 2.5-bit capacitor-flip-over multiplying digital-to-analog converter (MDAC) stage is modified for the injection of large magnitude dithering by adding six additional comparators, and thus only three correction parameters in every stage subjected to correction were measured and extracted by a simple calibration algorithm with multibit first stage. Behavioral simulation results show that, using the proposed calibration technique, the signal-to-noise-and-distortion ratio improves from 63.3 to 79.3dB and the spurious-free dynamic range is increased from 63.9 to 96.4dB after calibrating the first two stages, in a 14-bit 100-MS/s pipelined ADC with σ=0.2% capacitor mismatches and 60dB nonideal opamp gain. The time of calibrating the first two stages is around 1.34 seconds for the modeled ADC.