Time-of-flight (TOF) range imaging is a promising technology for various applications such as touchless control, augmented reality interface, and automotive. The TOF range imagers are classified into two methods: direct TOF with single photo avalanche diodes and indirect TOF with lock-in pixels. The indirect TOF range imagers have advantages in terms of a high spatial resolution and high depth precision because their pixels are simple and can handle many photons at one time. This paper reviews and discusses principal lock-in pixels reported both in the past and present, including circuit-based and charge-modulator-based lock-in pixels. In addition, key technologies that include enhancing sensitivity and background suppression techniques are also discussed.

We review recently obtained results for CMOS (Complementary Metal Oxide Semiconductor) imaging devices used in biomedical applications. The topics include dish type image sensors, deep-brain implantation devices for small animals, and retinal prosthesis devices. Fundamental device structures and their characteristics are described, and the results of in vivo experiments are presented.