We investigated suitable spatial inverse filters for cortical dipole imaging from the scalp electroencephalogram (EEG). The effects of incorporating statistical information of signal and noise into inverse procedures were examined by computer simulations and experimental studies. The parametric projection filter (PPF) and parametric Wiener filter (PWF) were applied to an inhomogeneous three-sphere volume conductor head model. The noise covariance matrix was estimated by applying independent component analysis (ICA) to scalp potentials. The present simulation results suggest that the PPF and the PWF provided excellent performance when the noise covariance was estimated from the differential noise between EEG and the separated signal using ICA and the signal covariance was estimated from the separated signal. Moreover, the spatial resolution of the cortical dipole imaging was improved while the influence of noise was suppressed by including the differential noise at the instant of the imaging and by adjusting the duration of noise sample according to the signal to noise ratio. We applied the proposed imaging technique to human experimental data of visual evoked potential and obtained reasonable results that coincide to physiological knowledge.

In this study, we propose a method of classifying a spontaneous electroencephalogram (EEG) approach to a brain-computer interface. Ten subjects, aged 21-32 years, volunteered to imagine left- and right-hand movements. An independent component analysis based on a fixed-point algorithm is used to eliminate the activities found in the EEG signals. We use a fractal dimension value to reveal the embedded potential responses in the human brain. The different fractal dimension values between the relaxing and imaging periods are computed. Featured data is classified by a three-layer feed-forward neural network based on a simple backpropagation algorithm. Two conventional methods, namely, the use of the autoregressive (AR) model and the band power estimation (BPE) as features, and the linear discriminant analysis (LDA) as a classifier, are selected for comparison in this study. Experimental results show that the proposed method is more effective than the conventional methods.

An alternative human interface enabling the handicapped with severe motor disabilities to control an assistive system is presented. Since this interface relies on the biosignals originating from the contraction of muscles on the face during particular movements, even individuals with a paralyzed limb can use it with ease. For real-world application, a dedicated hardware module employing a general-purpose DSP was implemented and its validity tested on an electrically powered wheelchair. Furthermore, an additional attempt to reduce error rates to a minimum for stable operation was also made based on the entropy information inherent in the signals during the classification phase. In the experiments in which 11 subjects participated, it was found most of them could control the target system at their own will, and thus the proposed interface could be considered a potential alternative for the interaction of the severely handicapped with electronic systems.

The electroencephalogram (EEG) has become a widely used tool for investigating brain function. Brain signal source localization is a process of inverse calculation from sensor information (electric potentials for EEG) to the identification of multiple brain sources to obtain the locations and orientation parameters. In this paper, we describe a combination of the backpropagation neural network (BPNN) with the nonlinear least-square (NLS) method to localize two dipoles with reasonable accuracy and speed from EEG data computerized by two dipoles randomly positioned in the brain. The trained BPNN, obtains the initial values for the two dipoles through fast calculation and also avoids the influence of noise. Then the NLS method (Powell algorithm) is used to accurately estimate the two dipole parameters. In this study, we also obtain the minimum distance between the assumed dipole pair, 0.8 cm, in order to localize two sources from a smaller limited distance between the dipole pair. The present simulation results demonstrate that the combined method can allow us to localize two dipoles with high speed and accuracy, that is, in 20 seconds and with the position error of around 6.5%, and to reduce the influence of noise.

The goal of source localization in the brain is to estimate a set of parameters for representing source characteristics; one of such parameters is the source number. We here propose a method combining the Powell algorithm with the information criterion method for determining the optimal dipole number. The potential errors can be calculated by the Powell algorithm with the concentric 4-sphere head model and 32 electrodes, then the number of dipoles is determined by the information criterion method with the potential errors mentioned above. This method has the advantages of a high identification accuracy of dipole number and a small number of EEG data because in this method: (1) only one EEG topography is used in the computation, (2) 32 electrodes are used to obtain the EEG data, (3) the optimal dipole number can be obtained by this method. In order to prove our method to be efficient, precise and robust to noise, 10% white noise is introduced to test this method theoretically. Some investigations are presented here to show our method is an advanced approach for determining the optimal dipole number.

A method for a genuinely multivariate analysis of statistical phase synchronization phenomena in empirical data is presented. It is applied to EEG data from a psychological experiment, obtaining results which indicate a possible relevance of this method in the context of cognitive science as well as in other fields.

The objective of this study was to explore suitable spatial filters for inverse estimation of cortical potentials from the scalp electroencephalogram. The effect of incorporating noise covariance into inverse procedures was examined by computer simulations. The parametric projection filter, which allows inverse estimation with the presence of information on the noise covariance, was applied to an inhomogeneous three-concentric-sphere model under various noise conditions in order to estimate the cortical potentials from the scalp potentials. The present simulation results suggest that incorporation of information on the noise covariance allows better estimation of cortical potentials, than inverse solutions without knowledge about the noise covariance, when the correlation between the signal and noise is low. The method for determining the optimum regularization parameter, which can be applied for parametric inverse techniques, is also discussed.

A problem of estimating biopotential sources in the brain based on EEG signals observed on the scalp is known as an important inverse problem of electrophysiology. Usually there is no closed-form solution for this problem and it requires iterative techniques such as the Levenberg-Marquardt algorithm. Considering the nonlinear properties of inverse problem, and signal to noise ratio inherent in EEG signals, a back propagation neural network has been recently proposed as a solution. In this paper, we investigated the properties of neural networks and its localization accuracy for single dipole source localization. Based on the results of extensive studies, we concluded the neural networks are highly feasible in single-source localization with a small number of electrodes (18 electrodes), also examined the usefulness of this method for clinical application with a case of epilepsy.

Recently there has been increased attention to the causality among biomedical signals. The causality between brain structures involved in the generation of alpha activity is examined based on EEG signals acquired simultaneously in the frontal and occipital regions of the scalp. The concept of directed coherence (DC) is introduced as a means of resolving two-signal observations into the constituent components of original signals, the interaction between signals and the influence of one signal source on the other, through autoregressive modeling. The technique was applied to EEG recorded from 11 normal subjects with eyes closed. Through an analysis of the directed coherence, it was found that in both the left and right hemispheres, alpha rhythms with relatively low frequency had a significantly higher correlation in the frontal-occipital direction than in the opposite direction. In the upper alpha frequency band, a significantly higher DC was observed in the occipital-frontal direction, and the right-left DC in the occipital area was consistently higher. The activity of rhythms near 10 Hz was widespread. These results suggest that there is a difference in the genesis and the structure of information transmission in the lower and upper band, and for 10-Hz alpha waves.

In this paper, an attempt was made to evaluate mental workload using chaotic analysis of EEG. EEG signals registered from Fz and Cz during a mental task (mental addition) were recorded and analyzed using attractor plots, fractal dimensions, and Lyapunov exponents in order to clarify chaotic dynamics and to investigate whether mental workload can be assessed using these chaotic measures. The largest Lyapunov exponent for all experimental conditions took positive values, which indicated chaotic dynamics in the EEG signals. However, we could not evaluate mental workload using the largest Lyapunov exponent or attractor plot. The fractal dimension, on the other hand, tended to increase with the work level. We concluded that the fractal dimension might be used to evaluate a mental state, especially a mental workload induced by mental task loading.

Analysis of electroencephalogram (EEG) is presented for sleep physiology. This analysis is performed by the Instantaneous Maximum Entropy Method (IMEM), which was given by the author. Appearance and continuation of featuristic waves are not steady in EEG. The characteristics of these waves responding to epoch of sleep are analyzed. The behaviours of waves were clarified by this analysis as follows; (a) time dependent frequency of continuous oscillations of alpha rhythm was observed precisely. Sleep spindles were detected clearly within NREM and these parameters of time, frequency, and peak energy were specified. (b) delta waves with very low frequencies and sleep spindles were observed simultaneously. And (c) the relationship of sleep spindles and delta waves was first detected with negative correlation along time-axis. The analysis by the IMEM was found effective comparing conventional analysis method of FFT, bandpass filter bank, etc.