To provide basic considerations for the realization of method for suppressing the EMI from differential-paired lines on flexible printed circuits (FPC), the characteristics of the SI performance and shielding effectiveness (SE) of shielded-flexible printed circuits for differential-signaling are investigated in this paper experimentally and by a numerical modeling. Firstly, transmission characteristics of TDR measurement and frequency response of |Sdd21| are discussed, from view point of signal integrity. Secondly, as the characteristics of the SE performance for EMI, frequency responses of magnetic field are investigated. Although placement of conductive shield near the paired-lines decreases characteristics impedance, |Sdd21| for the “with Cu 5.5 µm-thickness copper shield” is not deteriorated compared with “without shield” and sufficient SE performance for magnetic field can be established. But, thin-shield deteriorates SI as well as SE performances. The frequency response of |Sdd21| at higher frequencies for the “Ag 0.1 µm” case has the steep loss roll off. A reflection loss resulted from impedance-mismatching is not dominant factor of the losses. The dominant factor may be magnetic field leakage due to very thin-conductive shield.