In this paper, we propose an adaptive voltage huddle-based distributed-register architecture (AVHDR architecture), which integrates dynamic multiple supply voltages and interconnection delay into high-level synthesis. In AVHDR architecture, voltages can be dynamically assigned for energy reduction. In other words, low supply voltages are assigned to non-critical operations, and leakage power is cut off by turning off the power supply to the sleeping functional units. Next, an AVHDR-based high-level synthesis algorithm is proposed. Our algorithm is based on iterative improvement of scheduling/binding and floorplanning. In the iteration process, the modules in each huddle can be placed close to each other and the corresponding AVHDR architecture can be generated and optimized with floorplanning information. Experimental results show that on average our algorithm achieves 43.9% energy-saving compared with conventional algorithms.