This paper describes a high-speed D/A converter design for mixed-mode systems. Capacitive coupling induced by inter-chip interconnects and time-variant clock skew between ICs should be considered for mixed-mode systems, and on-chip interconnects should be treated as transmission lines in the circuit simulation as operating speed reaches GHz range. A robust FIFO built in the D/A converter can absorb input data timing variance due to the capacitive coupling and the clock timing skew, the worst-case margin of which is 1.5TCLK. Distributed RLC transmission line models for on-chip interconnects produce accurate simulation results at 1 GHz clock frequency over lumped models. For optimized D/A converter design, behavioral modeling methodology is also presented in this paper. Measurement results verify the accuracy of the on-chip interconnect and behavioral models.