The IEEE 802.16j mobile multi-hop relay (MMR) is studied to improve throughput, extend coverage, and increase capacity. Mobile relay stations attached to vehicles make arbitrary movements and have interference with other base stations or relay stations, thus lowering service functions. This study sets out to suggest an interference detection and avoidance method and evaluates its performance in order to help introduce a mobile relay station for vehicle mounting in a mobile multi-hop relay network. The proposed approach would be implemented by the addition of MAC management messages at a base or relay station instead of the change of mobile station.