In the context of Web 2.0, the interaction between users and resources is more and more frequent in the process of resource sharing and consumption. However, the current research on resource pricing mainly focuses on the attributes of the resource itself, and does not weigh the interests of the resource sharing participants. In order to deal with these problems, the pricing mechanism of resource-user interaction evaluation based on multi-agent game theory is established in this paper. Moreover, the user similarity, the evaluation bias based on link analysis and punishment of academic group cheating are also included in the model. Based on the data of 181 scholars and 509 articles from the Wanfang database, this paper conducts 5483 pricing experiments for 13 months, and the results show that this model is more effective than other pricing models - the pricing accuracy of resource resources is 94.2%, and the accuracy of user value evaluation is 96.4%. Besides, this model can intuitively show the relationship within users and within resources. The case study also exhibits that the user's knowledge level is not positively correlated with his or her authority. Discovering and punishing academic group cheating is conducive to objectively evaluating researchers and resources. The pricing mechanism of scientific and technological resources and the users proposed in this paper is the premise of fair trade of scientific and technological resources.