The purpose of this study was to identify the key variables that determine the quality of the auditory environment, for the purposes of workplace auditory design and assessment. To this end, we characterized changes in oscillatory neural activity in electroencephalographic (EEG) data recorded from subjects who performed an intellectual activity while exposed to fluctuating ambient noise. Seven healthy men participated in the study. Subjects performed a verbal and spatial task that used the 3-back task paradigm to study working memory. During the task, subjects were presented with auditory stimuli grouped by increasing high-frequency content: (1) a sound with frequencies similar to Brownian noise and no modulation; (2) an amplitude-modulated sound with frequencies similar to white noise; (3) amplitude-modulated pink noise; and (4) amplitude-modulated Brownian noise. Upon presentation, we observed a characteristic change in three EEG bands: theta (4-8Hz), alpha (8-13Hz), and beta (13-30Hz). In particular, a frequency-dependent enhancement and reduction of power was observed in the theta and beta bands, respectively.

The concept of a "standardized brain" is familiar in modern functional neuro-imaging techniques including PET and fMRI, but it has never been adopted for optical imaging studies that deal with a regional cortical area rather than the whole brain. In this paper, we propose a "standardized barrel cortex" for rodents, and present a method for mapping optically detected neural activity onto the standard cortex. The standard cortex is defined as a set of simple cortical columns, which are modeled on the cytoarchitectonic patterns of cell aggregates in cortical layer IV of the barrel cortex. Referring to its underlying anatomical structure, the method warps the surface image of individual cortices to fit the standard cortex. The cortex is warped using a two-dimensional free-form deformation technique with direct manipulation. Since optical imaging provides a map of neural activity on the cortical surface, the warping consequently remaps it on the standard cortex. Data presented in this paper show that somatosensory evoked neural activity is successfully represented on the standardized cortex, suggesting that the combination of optical imaging with our method is a promising approach for investigating the functional architecture of the cortex.