This paper proposes a novel access control scheme with collision detection that utilizes multiple-input multiple-output (MIMO) technology. Carrier sense multiple access with collision detection (CSMA/CD) is used in Ethernet wired local area networks (LANs) for media access control (MAC). CSMA/CD can immediately abort a transmission if any collision is detected and is thus able to change to a retransmission state. In Ethernet, CSMA/CD results in a transmission efficiency of approximately 90% because the protocol makes the transmission band available for useful communication by this retransmission function. Conversely, in conventional wireless LANs (WLANs), the packet collisions due to interfering signals and the retransmission due to collisions are significant issues. Because conventional WLANs cannot detect packet collisions during signal transmission, the success of a transmission can only be determined by whether an acknowledgment (ACK) frame has been received. Consequently, the transmission efficiency is low — approximately 60%. The objective of our study is to increase the transmission efficiency of WLANs to make it at least equal to that of Ethernet. Thus, we propose a novel access control scheme with collision detection that utilizes MIMO technology. When preamble signals are transmitted before transmitting data packets from an antenna, the proposed scheme can detect packet collisions during signal transmission at another antenna; then, the affected packets are retransmitted immediately. Two fundamental technologies are utilized to realize our proposed scheme. The first technology is the access control protocol in the MAC layer in the form of the MIMO frame sequence protocol, which is used to detect signal interference. The other technology is signal processing in the physical (PHY) layer that actualizes collision detection. This paper primarily deals with the proposed MAC layer scheme, which is evaluated by theoretical analyses and computer simulations. Evaluation by computer simulations indicate that the proposed scheme in a transmission efficiency of over 90%.