Clinical researches show that the morbidity of coronary artery disease (CAD) is gradually increasing in many countries every year, and it causes hundreds of thousands of people all over the world dying for each year. As the optical coherence tomography with high resolution and better contrast applied to the lesion tissue investigation of human vessel, many more micro-structures of the vessel could be easily and clearly visible to doctors, which help to improve the CAD treatment effect. Manual qualitative analysis and classification of vessel lesion tissue are time-consuming to doctors because a single-time intravascular optical coherence (IVOCT) data set of a patient usually contains hundreds of in-vivo vessel images. To overcome this problem, we focus on the investigation of the superficial layer of the lesion region and propose a model based on local multi-layer region for vessel lesion components (lipid, fibrous and calcified plaque) features characterization and extraction. At the pre-processing stage, we applied two novel automatic methods to remove the catheter and guide-wire respectively. Based on the detected lumen boundary, the multi-layer model in the proximity lumen boundary region (PLBR) was built. In the multi-layer model, features extracted from the A-line sub-region (ALSR) of each layer was employed to characterize the type of the tissue existing in the ALSR. We used 7 human datasets containing total 490 OCT images to assess our tissue classification method. Validation was obtained by comparing the manual assessment with the automatic results derived by our method. The proposed automatic tissue classification method achieved an average accuracy of 89.53%, 93.81% and 91.78% for fibrous, calcified and lipid plaque respectively.

In this paper we propose a novel classification method for the multiple k-nearest neighbor (MkNN) classifier and show its practical application to medical image processing. The proposed method performs fine classification when a pair of the spatial coordinate of the observation data in the observation space and its corresponding feature vector in the feature space is provided. The proposed MkNN classifier uses the continuity of the distribution of features of the same class not only in the feature space but also in the observation space. In order to validate the performance of the present method, it is applied to the tissue characterization problem of coronary plaque. The quantitative and qualitative validity of the proposed MkNN classifier have been confirmed by actual experiments.

In this paper, we propose a fully automatic method for extracting carotid artery contours from ultrasound images based on an active contour approach. Several contour extraction techniques have been proposed to measure carotid artery walls for early detection of atherosclerotic disease. However, the majority of these techniques require a certain degree of user interaction that demands time and effort. Our proposal automatically detects the position of the carotid artery by identifying blood flow information related to the carotid artery, and an active contour model is employed that uses initial contours placed in the detected position. Our method also applies a global energy minimization scheme to the active contour model. Experiments on clinical cases show that the proposed method automatically extracts the carotid artery contours at an accuracy close to that achieved by manual extraction.