Since the power consumption of FPGA is larger than that of ASIC under the condition to perform the same function using the same scaling, the application of FPGA is limited especially in portable electronic devices. In this paper, we propose a novel low-power FPGA architecture based on coarse-grained power gating to reduce power consumption. The new placement algorithm and routing resource graph for sleep regions is also presented. After enhancing the CAD framework, a detailed discussion is given under different region size supported by the new FPGA architecture. As a result, our proposed FPGA architecture combined with the new placement and routing algorithm can reduce 19.4% in the total power consumption compared with the traditional FPGA. By using our proposed method, FPGA is promising to be widely applied to portable devices.