Electron Transfer Mediated Biosensor with Plasma-Polymerized Film Containing Redox Site
Summary :
An electron transfer mediated amperometric enzyme biosensor based on a plasma-polymerized thin film of dimethylaminomethylferrocene (DMAMFc) is reported. A nanoscale thin polymer film containing a redox mediator was plasma-deposited directly onto an electrode with physisorbed glucose oxidase (GOD). Since the redox sites were introduced in the vicinity of the reaction centers of GOD, a highly efficient electron transfer system was formed in which almost all the reaction centers of GOD were connected to redox sites of the polymer matrix. The advantages of this strategy were: no need for prior or further chemical modification of the enzyme molecules, and simplicity of design compared with the use of a conventional polymer matrix. Moreover, the fact that the film deposition was performed using a microfabrication-compatible organic plasma promised great potential for high-throughput production of bioelectronic devices.
- Publication
- IEICE TRANSACTIONS on Electronics Vol.E89-C No.12 pp.1781-1785
- Publication Date
- 2006/12/01
- Publicized
- Online ISSN
- 1745-1353
- DOI
- 10.1093/ietele/e89-c.12.1781
- Type of Manuscript
- Special Section PAPER (Special Section on Towards the Realization of Organic Molecular Electronics)
- Category
- Bioelectronics and Sensors
Authors
Keyword
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Hitoshi MUGURUMA, Hideyuki UEHARA, "Electron Transfer Mediated Biosensor with Plasma-Polymerized Film Containing Redox Site" in IEICE TRANSACTIONS on Electronics,
vol. E89-C, no. 12, pp. 1781-1785, December 2006, doi: 10.1093/ietele/e89-c.12.1781.
Abstract: An electron transfer mediated amperometric enzyme biosensor based on a plasma-polymerized thin film of dimethylaminomethylferrocene (DMAMFc) is reported. A nanoscale thin polymer film containing a redox mediator was plasma-deposited directly onto an electrode with physisorbed glucose oxidase (GOD). Since the redox sites were introduced in the vicinity of the reaction centers of GOD, a highly efficient electron transfer system was formed in which almost all the reaction centers of GOD were connected to redox sites of the polymer matrix. The advantages of this strategy were: no need for prior or further chemical modification of the enzyme molecules, and simplicity of design compared with the use of a conventional polymer matrix. Moreover, the fact that the film deposition was performed using a microfabrication-compatible organic plasma promised great potential for high-throughput production of bioelectronic devices.
URL: https://global.ieice.org/en_transactions/electronics/10.1093/ietele/e89-c.12.1781/_p
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@ARTICLE{e89-c_12_1781,
author={Hitoshi MUGURUMA, Hideyuki UEHARA, },
journal={IEICE TRANSACTIONS on Electronics},
title={Electron Transfer Mediated Biosensor with Plasma-Polymerized Film Containing Redox Site},
year={2006},
volume={E89-C},
number={12},
pages={1781-1785},
abstract={An electron transfer mediated amperometric enzyme biosensor based on a plasma-polymerized thin film of dimethylaminomethylferrocene (DMAMFc) is reported. A nanoscale thin polymer film containing a redox mediator was plasma-deposited directly onto an electrode with physisorbed glucose oxidase (GOD). Since the redox sites were introduced in the vicinity of the reaction centers of GOD, a highly efficient electron transfer system was formed in which almost all the reaction centers of GOD were connected to redox sites of the polymer matrix. The advantages of this strategy were: no need for prior or further chemical modification of the enzyme molecules, and simplicity of design compared with the use of a conventional polymer matrix. Moreover, the fact that the film deposition was performed using a microfabrication-compatible organic plasma promised great potential for high-throughput production of bioelectronic devices.},
keywords={},
doi={10.1093/ietele/e89-c.12.1781},
ISSN={1745-1353},
month={December},}
Copy
TY - JOUR
TI - Electron Transfer Mediated Biosensor with Plasma-Polymerized Film Containing Redox Site
T2 - IEICE TRANSACTIONS on Electronics
SP - 1781
EP - 1785
AU - Hitoshi MUGURUMA
AU - Hideyuki UEHARA
PY - 2006
DO - 10.1093/ietele/e89-c.12.1781
JO - IEICE TRANSACTIONS on Electronics
SN - 1745-1353
VL - E89-C
IS - 12
JA - IEICE TRANSACTIONS on Electronics
Y1 - December 2006
AB - An electron transfer mediated amperometric enzyme biosensor based on a plasma-polymerized thin film of dimethylaminomethylferrocene (DMAMFc) is reported. A nanoscale thin polymer film containing a redox mediator was plasma-deposited directly onto an electrode with physisorbed glucose oxidase (GOD). Since the redox sites were introduced in the vicinity of the reaction centers of GOD, a highly efficient electron transfer system was formed in which almost all the reaction centers of GOD were connected to redox sites of the polymer matrix. The advantages of this strategy were: no need for prior or further chemical modification of the enzyme molecules, and simplicity of design compared with the use of a conventional polymer matrix. Moreover, the fact that the film deposition was performed using a microfabrication-compatible organic plasma promised great potential for high-throughput production of bioelectronic devices.
ER -
English
