Amperometric Biosensor with Composites of Carbon Nanotube, Hexaamineruthenium(III)chloride, and Plasma-Polymerized Film

Tatsuya HOSHINO; Takahiro INOUE; Hitoshi MUGURUMA

doi:10.1587/transele.E96.C.1536

Amperometric Biosensor with Composites of Carbon Nanotube, Hexaamineruthenium(III)chloride, and Plasma-Polymerized Film

Tatsuya HOSHINO, Takahiro INOUE, Hitoshi MUGURUMA

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A novel fabrication approach for the amperometric biosensor composed of carbon nanotubes (CNT), a plasma-polymerized film (PPF), hexamineruthenium(III)chloride (RU), and enzyme glucose oxidase (GOD) is reported. The configuration of the electrochemical electrode is multilayer films which contain sputtered gold, lower acetonitrile PPF, CNT, RU, GOD, and upper acetonitrile PPF, sequentially. First, PPF deposited on Au acts as a permselective membrane and as a scaffold for CNT layer formation. Second, PPF directly deposited on GOD acts as a matrix for enzyme immobilization. To facilitate the electrochemical communication between the CNT layer and GOD, CNT was treated with nitrogen plasma. The electron transfer mediator RU play a role as the mediator, in which the electron caused by enzymatic reaction transports to the electrode. The synergy between the electron transfer mediator and CNT provides benefits in terms of lowering the operational potential and enhancing the sensitivity (current). The optimized glucose biosensor revealed a sensitivity of 3.4µA mM^-1 cm^-2 at +0.4V vs. Ag/AgCl, linear dynamic range of 2.5-19mM, and a response time of 6s.

Publication: IEICE TRANSACTIONS on Electronics Vol.E96-C No.12 pp.1536-1540

Publication Date: 2013/12/01

Publicized

Online ISSN: 1745-1353

DOI: 10.1587/transele.E96.C.1536

Type of Manuscript: PAPER

Category: Organic Molecular Electronics

Authors

Tatsuya HOSHINO
  Shibaura Institute of Technology
Takahiro INOUE
  Shibaura Institute of Technology
Hitoshi MUGURUMA
  Shibaura Institute of Technology

Keyword

plasma-polymerized film, carbon nanotube, hexaamineruthenium(III)chloride, amperometric biosensensor, glucose oxidase

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Tatsuya HOSHINO, Takahiro INOUE, Hitoshi MUGURUMA, "Amperometric Biosensor with Composites of Carbon Nanotube, Hexaamineruthenium(III)chloride, and Plasma-Polymerized Film" in IEICE TRANSACTIONS on Electronics, vol. E96-C, no. 12, pp. 1536-1540, December 2013, doi: 10.1587/transele.E96.C.1536.
Abstract: A novel fabrication approach for the amperometric biosensor composed of carbon nanotubes (CNT), a plasma-polymerized film (PPF), hexamineruthenium(III)chloride (RU), and enzyme glucose oxidase (GOD) is reported. The configuration of the electrochemical electrode is multilayer films which contain sputtered gold, lower acetonitrile PPF, CNT, RU, GOD, and upper acetonitrile PPF, sequentially. First, PPF deposited on Au acts as a permselective membrane and as a scaffold for CNT layer formation. Second, PPF directly deposited on GOD acts as a matrix for enzyme immobilization. To facilitate the electrochemical communication between the CNT layer and GOD, CNT was treated with nitrogen plasma. The electron transfer mediator RU play a role as the mediator, in which the electron caused by enzymatic reaction transports to the electrode. The synergy between the electron transfer mediator and CNT provides benefits in terms of lowering the operational potential and enhancing the sensitivity (current). The optimized glucose biosensor revealed a sensitivity of 3.4µA mM^-1 cm^-2 at +0.4V vs. Ag/AgCl, linear dynamic range of 2.5-19mM, and a response time of 6s.
URL: https://global.ieice.org/en_transactions/electronics/10.1587/transele.E96.C.1536/_p

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@ARTICLE{e96-c_12_1536,
author={Tatsuya HOSHINO, Takahiro INOUE, Hitoshi MUGURUMA, },
journal={IEICE TRANSACTIONS on Electronics},
title={Amperometric Biosensor with Composites of Carbon Nanotube, Hexaamineruthenium(III)chloride, and Plasma-Polymerized Film},
year={2013},
volume={E96-C},
number={12},
pages={1536-1540},
abstract={A novel fabrication approach for the amperometric biosensor composed of carbon nanotubes (CNT), a plasma-polymerized film (PPF), hexamineruthenium(III)chloride (RU), and enzyme glucose oxidase (GOD) is reported. The configuration of the electrochemical electrode is multilayer films which contain sputtered gold, lower acetonitrile PPF, CNT, RU, GOD, and upper acetonitrile PPF, sequentially. First, PPF deposited on Au acts as a permselective membrane and as a scaffold for CNT layer formation. Second, PPF directly deposited on GOD acts as a matrix for enzyme immobilization. To facilitate the electrochemical communication between the CNT layer and GOD, CNT was treated with nitrogen plasma. The electron transfer mediator RU play a role as the mediator, in which the electron caused by enzymatic reaction transports to the electrode. The synergy between the electron transfer mediator and CNT provides benefits in terms of lowering the operational potential and enhancing the sensitivity (current). The optimized glucose biosensor revealed a sensitivity of 3.4µA mM^-1 cm^-2 at +0.4V vs. Ag/AgCl, linear dynamic range of 2.5-19mM, and a response time of 6s.},
keywords={},
doi={10.1587/transele.E96.C.1536},
ISSN={1745-1353},
month={December},}

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TY - JOUR
TI - Amperometric Biosensor with Composites of Carbon Nanotube, Hexaamineruthenium(III)chloride, and Plasma-Polymerized Film
T2 - IEICE TRANSACTIONS on Electronics
SP - 1536
EP - 1540
AU - Tatsuya HOSHINO
AU - Takahiro INOUE
AU - Hitoshi MUGURUMA
PY - 2013
DO - 10.1587/transele.E96.C.1536
JO - IEICE TRANSACTIONS on Electronics
SN - 1745-1353
VL - E96-C
IS - 12
JA - IEICE TRANSACTIONS on Electronics
Y1 - December 2013
AB - A novel fabrication approach for the amperometric biosensor composed of carbon nanotubes (CNT), a plasma-polymerized film (PPF), hexamineruthenium(III)chloride (RU), and enzyme glucose oxidase (GOD) is reported. The configuration of the electrochemical electrode is multilayer films which contain sputtered gold, lower acetonitrile PPF, CNT, RU, GOD, and upper acetonitrile PPF, sequentially. First, PPF deposited on Au acts as a permselective membrane and as a scaffold for CNT layer formation. Second, PPF directly deposited on GOD acts as a matrix for enzyme immobilization. To facilitate the electrochemical communication between the CNT layer and GOD, CNT was treated with nitrogen plasma. The electron transfer mediator RU play a role as the mediator, in which the electron caused by enzymatic reaction transports to the electrode. The synergy between the electron transfer mediator and CNT provides benefits in terms of lowering the operational potential and enhancing the sensitivity (current). The optimized glucose biosensor revealed a sensitivity of 3.4µA mM^-1 cm^-2 at +0.4V vs. Ag/AgCl, linear dynamic range of 2.5-19mM, and a response time of 6s.
ER -