Behavior of Magnetic Particles within Cells Reflecting the Movements of the Intracellular Microstructures and Ingesting Activities of Cells

Iku NEMOTO; Kazuhito OGURA; Hideki TOYOTAMA

Behavior of Magnetic Particles within Cells Reflecting the Movements of the Intracellular Microstructures and Ingesting Activities of Cells

Iku NEMOTO, Kazuhito OGURA, Hideki TOYOTAMA

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Magnetic particles such as Fe₃O₄ and - Fe₂O₃ introduced into hamster pulmonary macrophages were used as a probe for intracellular motility and the rate of phagocytosis. Magnetic particles within the macrophages produce a weak magnetic field around the cells when magnetized with a strong external magnetic field. The field decays with time with a half time less than 5-6 minutes. This decay called relaxation has been recently associated with intracellular movements of microstructures of the cells. In this paper we present the results of relaxation measurements under the influence of inhibitors of ATP synthesis. We also measured the change of relaxation rate during phagocytosis (taking up of the particles by the cells.) The inhibitors notably decreased the rate of relaxation as had been expected. The decrease in the rate of relaxation corresponded well to the decrease in intracellular ATP concentration which was measured by the luciferin-luciferase method. The change of relaxation during phagocytosis of magnetic particules by pulmonary macrophages was clearly seen.

Publication: IEICE TRANSACTIONS on transactions Vol.E69-E No.11 pp.1231-1240

Publication Date: 1986/11/25

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Type of Manuscript: PAPER

Category: Medical Electronics and Bioengineering

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Iku NEMOTO
Kazuhito OGURA
Hideki TOYOTAMA

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Iku NEMOTO, Kazuhito OGURA, Hideki TOYOTAMA, "Behavior of Magnetic Particles within Cells Reflecting the Movements of the Intracellular Microstructures and Ingesting Activities of Cells" in IEICE TRANSACTIONS on transactions, vol. E69-E, no. 11, pp. 1231-1240, November 1986, doi: .
Abstract: Magnetic particles such as Fe₃O₄ and - Fe₂O₃ introduced into hamster pulmonary macrophages were used as a probe for intracellular motility and the rate of phagocytosis. Magnetic particles within the macrophages produce a weak magnetic field around the cells when magnetized with a strong external magnetic field. The field decays with time with a half time less than 5-6 minutes. This decay called relaxation has been recently associated with intracellular movements of microstructures of the cells. In this paper we present the results of relaxation measurements under the influence of inhibitors of ATP synthesis. We also measured the change of relaxation rate during phagocytosis (taking up of the particles by the cells.) The inhibitors notably decreased the rate of relaxation as had been expected. The decrease in the rate of relaxation corresponded well to the decrease in intracellular ATP concentration which was measured by the luciferin-luciferase method. The change of relaxation during phagocytosis of magnetic particules by pulmonary macrophages was clearly seen.
URL: https://global.ieice.org/en_transactions/transactions/10.1587/e69-e_11_1231/_p

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@ARTICLE{e69-e_11_1231,
author={Iku NEMOTO, Kazuhito OGURA, Hideki TOYOTAMA, },
journal={IEICE TRANSACTIONS on transactions},
title={Behavior of Magnetic Particles within Cells Reflecting the Movements of the Intracellular Microstructures and Ingesting Activities of Cells},
year={1986},
volume={E69-E},
number={11},
pages={1231-1240},
abstract={Magnetic particles such as Fe₃O₄ and - Fe₂O₃ introduced into hamster pulmonary macrophages were used as a probe for intracellular motility and the rate of phagocytosis. Magnetic particles within the macrophages produce a weak magnetic field around the cells when magnetized with a strong external magnetic field. The field decays with time with a half time less than 5-6 minutes. This decay called relaxation has been recently associated with intracellular movements of microstructures of the cells. In this paper we present the results of relaxation measurements under the influence of inhibitors of ATP synthesis. We also measured the change of relaxation rate during phagocytosis (taking up of the particles by the cells.) The inhibitors notably decreased the rate of relaxation as had been expected. The decrease in the rate of relaxation corresponded well to the decrease in intracellular ATP concentration which was measured by the luciferin-luciferase method. The change of relaxation during phagocytosis of magnetic particules by pulmonary macrophages was clearly seen.},
keywords={},
doi={},
ISSN={},
month={November},}

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TY - JOUR
TI - Behavior of Magnetic Particles within Cells Reflecting the Movements of the Intracellular Microstructures and Ingesting Activities of Cells
T2 - IEICE TRANSACTIONS on transactions
SP - 1231
EP - 1240
AU - Iku NEMOTO
AU - Kazuhito OGURA
AU - Hideki TOYOTAMA
PY - 1986
DO -
JO - IEICE TRANSACTIONS on transactions
SN -
VL - E69-E
IS - 11
JA - IEICE TRANSACTIONS on transactions
Y1 - November 1986
AB - Magnetic particles such as Fe₃O₄ and - Fe₂O₃ introduced into hamster pulmonary macrophages were used as a probe for intracellular motility and the rate of phagocytosis. Magnetic particles within the macrophages produce a weak magnetic field around the cells when magnetized with a strong external magnetic field. The field decays with time with a half time less than 5-6 minutes. This decay called relaxation has been recently associated with intracellular movements of microstructures of the cells. In this paper we present the results of relaxation measurements under the influence of inhibitors of ATP synthesis. We also measured the change of relaxation rate during phagocytosis (taking up of the particles by the cells.) The inhibitors notably decreased the rate of relaxation as had been expected. The decrease in the rate of relaxation corresponded well to the decrease in intracellular ATP concentration which was measured by the luciferin-luciferase method. The change of relaxation during phagocytosis of magnetic particules by pulmonary macrophages was clearly seen.
ER -