This paper proposes an ASIP performance optimization method taking clock frequency into account. The performance of an instruction set processor can be measured using the execution time of an application program, which can be determined by the clock cycles to perform the application program divided by the applied clock frequency. Therefore, the clock frequency should also be tuned in order to maximize the performance of the processor under the given design constraints. Experimental results show that the proposed method determines an optimal combination of FUs considering clock frequency.