Aiming at the problem of “energy hole” caused by random distribution of nodes in large-scale wireless sensor networks (WSNs), this paper proposes an adaptive energy-efficient balanced uneven clustering routing protocol (AEBUC) for WSNs. The competition radius is adaptively adjusted based on the node density and the distance from candidate cluster head (CH) to base station (BS) to achieve scale-controlled adaptive optimal clustering; in candidate CHs, the energy relative density and candidate CH relative density are comprehensively considered to achieve dynamic CH selection. In the inter-cluster communication, based on the principle of energy balance, the relay communication cost function is established and combined with the minimum spanning tree method to realize the optimized inter-cluster multi-hop routing, forming an efficient communication routing tree. The experimental results show that the protocol effectively saves network energy, significantly extends network lifetime, and better solves the “energy hole” problem.