This paper proposes a design method of a Doherty amplifier, which can determine the most efficient backed-off point of the amplifier by adjusting a load modulation parameter. The parameter is defined through the design of output transmission line of a carrier and a peak amplifier using a virtual open stub technique. This paper describes the design results using the technique to optimize efficiency of a Doherty amplifier for an orthogonal frequency division multiplexing (OFDM) signal, and parameter adjustment for a linearized Doherty amplifier using an adaptive digital predistortion (ADPD). Applying this method, the developed 250 W ADPD Doherty amplifier has achieved drain efficiency of 43.4% and intermodulation (IM) distortion of -48.3 dBc with output power of 44.1 dBm (10.1 dB output backed-off) at 563 MHz using an OFDM signal for integrated services digital broadcasting-terrestrial (ISDB-T).