A modularized, low-cost, and non-invasive electrochemical examination platform is proposed in this work. Melatonin has been found to be a possible significant indicator molecule in the detection of breast cancer. 3-hydroxyanthranilic acid and nuclear matrix protein 22 can be used as a significant index for potential bladder cancer risks. The proposed system was verified by measuring the melatonin, 3-hydroxyanthranilic acid and nuclear matrix protein 22. Cyclic voltammetry and molecularly imprinted polymers were used in the experiments. Screen-printed electrodes were coated with a film imprinted with target molecules. The measurement results of the proposed system were compared with those of a commercial potentiostat. The two sets of results were very similar. Moreover, the proposed system can be expanded to a four-channel system, which can perform four measurements simultaneously. The proposed system also provides convenient graphical user interface for real-time monitoring and records the information of the redox reactions.