A new hybrid brain-computer interface (BCI), which is based on sequential controls by eye tracking and steady-state visual evoked potentials (SSVEPs), has been proposed for high-speed spelling in virtual reality (VR) with a 40-target virtual keyboard. During target selection, gaze point was first detected by an eye-tracking accessory. A 4-target block was then selected for further target selection by a 4-class SSVEP BCI. The system can type at a speed of 1.25 character/sec in a cue-guided target selection task. Online experiments on three subjects achieved an averaged information transfer rate (ITR) of 360.7 bits/min.