This paper describes the performance improvement of power amplifiers by defected ground structure (DGS). Due to the excellent capability of harmonic rejection and tuning, DGS plays a great role in improving the major nonlinear behaviors of power amplifier such as output power, harmonics, power added efficiency (PAE), and the ratio between the carrier and the third order intermodulation distortion (C/IMD3). In order to verify the improvement of performances by DGS, measured data for a power amplifier, which adopts a 30 Watts LDMOS device for the operation at 2.1-2.2 GHz, are illustrated under several operating bias currents for two cases, i.e., with and without DGS attached. The principle of the improvement is described by the simple Volterra nonlinear transfer functions with the consideration of different operating classes. The obtained improvement of the 30 Watts power amplifier, under 400 mA of IdsQ as an example, includes the reduction in the second and third harmonics by 17 dB and 20 dB, and the increase in output power, PAE, and C/IMD3 by 1.3 Watts, 3.4%, and 4.7 dB, respectively.