This paper presents a multi-channel biomedical sensor system with system-level chopping and stochastic analog-to-digital (A/D) conversion techniques. The system-level chopping technique extends the input-signal bandwidth and reduces the interchannel crosstalk caused by multiplexing. The system-level chopping can replace an analog low-pass filter (LPF) with a digital filter and can reduce its area occupation. The stochastic A/D conversion technique realizes power-efficient resolution enhancement. A novel auto-calibration technique is also proposed for the stochastic A/D conversion technique. The proposed system includes a prototype analog front-end (AFE) IC fabricated using a 130 nm CMOS process. The fabricated AFE IC improved its interchannel crosstalk by 40 dB compared with the conventional analog chopping architecture. The AFE IC achieved SNDR of 62.9 dB at a sampling rate of 31.25 kSps while consuming 9.6 μW from a 1.2 V power supply. The proposed resolution enhancement technique improved the measured SNDR by 4.5 dB.