This paper proposes a post-layout transistor sizing method for crosstalk noise reduction. The proposed method downsizes the drivers of aggressor wires for noise reduction, utilizing the precise interconnect information extracted from the detail-routed layouts. We develop a transistor sizing algorithm for crosstalk noise reduction under delay constraints, and construct a crosstalk noise optimization method utilizing an analytic crosstalk noise model and a transistor sizing framework that have been developed. Our method exploits the transistor sizing framework that can vary transistor widths inside cells with interconnects unchanged. Our optimization method therefore never causes a new crosstalk noise problem, and does not need iterative layout optimization. The effectiveness of the proposed method is experimentally examined using 2 circuits. The maximum noise voltage is reduced by more than 50% without delay violation. These results show that the risk of crosstalk noise problems can be considerably reduced after detail-routing.