Control of complex networks such as gene regulatory networks is one of the fundamental problems in control theory. A Boolean network (BN) is one of the mathematical models in complex networks, and represents the dynamic behavior by Boolean functions. In this paper, a solution method for the finite-time control problem of BNs is proposed using a BDD (binary decision diagram). In this problem, we find all combinations of the initial state and the control input sequence such that a certain control specification is satisfied. The use of BDDs enables us to solve this problem for BNs such that the conventional method cannot be applied. First, after the outline of BNs and BDDs is explained, the problem studied in this paper is given. Next, a solution method using BDDs is proposed. Finally, a numerical example on a 67-node BN is presented.

Boolean networks (BNs) are considered as popular formal models for the dynamics of gene regulatory networks. There are many different types of BNs, depending on their updating scheme (synchronous, asynchronous, deterministic, or non-deterministic), such as Classical Random Boolean Networks (CRBNs), Asynchronous Random Boolean Networks (ARBNs), Generalized Asynchronous Random Boolean Networks (GARBNs), Deterministic Asynchronous Random Boolean Networks (DARBNs), and Deterministic Generalized Asynchronous Random Boolean Networks (DGARBNs). An important long-term behavior of BNs, so-called attractor, can provide valuable insights into systems biology (e.g., the origins of cancer). In the previous paper [1], we have studied properties of attractors of GARBNs, their relations with attractors of CRBNs, also proposed different algorithms for attractor detection. In this paper, we propose a new algorithm based on SAT-based bounded model checking to overcome inherent problems in these algorithms. Experimental results prove the effectiveness of the new algorithm. We also show that studying attractors of GARBNs can pave potential ways to study attractors of ARBNs.

This paper proposes a notion of a controllability measure of discrete-time piecewise affine systems, which is a natural extension of the controllability gramian of linear systems. Although this measure is calculated in a probabilistic way, it may be applied to control of biological systems for providing a policy to experiments for pharmaceutical developments. Thus an application to gene regulatory control of luminescence in the marine bacterium modeled by the piecewise affine system is discussed in this paper.