As semiconductor manufacturing processing scaling down, leakage current of CMOS circuits is becoming a dominant contributor to power dissipation. This paper provides an efficient leakage current reduction (LCR) technique for low-power and low-frequency circuit designs in terms of design rules and layout parameters related to layout dependent effects. We address the LCR technique both for analog and digital circuits, and present a design case when applying the LCR techniqe to a successive-approximation-register (SAR) analog-to-digital converter (ADC), which typically employs analog and digital transistors. In the post-layout simulation results by HSPICE, an SAR-ADC with the LCR technique achieves 38.6-nW as the total power consumption. Comparing with the design without the LCR technique, we attain about 30% total energy reduction.