An Implantable Sacral Nerve Root Recording and Stimulation System for Micturition Function Restoration

Yuan WANG; Xu ZHANG; Ming LIU; Weihua PEI; Kaifeng WANG; Hongda CHEN

doi:10.1587/transinf.2013EDP7395

IEICE TRANSACTIONS on Information

An Implantable Sacral Nerve Root Recording and Stimulation System for Micturition Function Restoration

Yuan WANG, Xu ZHANG, Ming LIU, Weihua PEI, Kaifeng WANG, Hongda CHEN

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This paper provides a prototype neural prosthesis system dedicated to restoring continence and micturition function for patients with lower urinary tract diseases, such as detrusor hyperreflexia and detrusor-sphincter dyssynergia. This system consists of an ultra low-noise electroneurogram (ENG) signal recording module, a bi-phasic electrical stimulator module and a control unit for closed-loop bladder monitoring and controlling. In order to record extremely weak ENG signal from extradural sacral nerve roots, the system provides a programmable gain from 80 dB to 117 dB. By combining of advantages of commercial-off-the-shelf (COTS) electronics and custom designed IC, the recording front-end acquires a fairly low input-referred noise (IRN) of 0.69 μV_rms under 300 Hz to 3 kHz and high area-efficiency. An on-chip multi-steps single slope analog-to-digital converter (ADC) is used to digitize the ENG signals at sampling rate of 10 kSPS and achieves an effective number of bits (ENOB) of 12.5. A bi-phasic current stimulus generator with wide voltage supply range (±0.9 V to ±12.5 V) and variable output current amplitude (0-500 μA) is introduced to overcome patient-depended impedance between electrode and tissue electrolyte. The total power consumption of the entire system is 5.61 mW. Recording and stimulation function of this system is switched by control unit with time division multiplexing strategy. The functionality of this proposed prototype system has been successfully verified through in-vivo experiments from dogs extradural sacral nerve roots.

Publication: IEICE TRANSACTIONS on Information Vol.E97-D No.10 pp.2790-2801

Publication Date: 2014/10/01

Publicized

Online ISSN: 1745-1361

DOI: 10.1587/transinf.2013EDP7395

Type of Manuscript: PAPER

Category: Biological Engineering

Authors

Yuan WANG
  Chinese Academy of Sciences
Xu ZHANG
  Chinese Academy of Sciences
Ming LIU
  Chinese Academy of Sciences
Weihua PEI
  Chinese Academy of Sciences
Kaifeng WANG
  People's Hospital of Peking University
Hongda CHEN
  Chinese Academy of Sciences

Keyword

neural prosthesis, functional electrical stimulation, closed-loop bladder control, acute animal experiment, spinal cord injury

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Yuan WANG, Xu ZHANG, Ming LIU, Weihua PEI, Kaifeng WANG, Hongda CHEN, "An Implantable Sacral Nerve Root Recording and Stimulation System for Micturition Function Restoration" in IEICE TRANSACTIONS on Information, vol. E97-D, no. 10, pp. 2790-2801, October 2014, doi: 10.1587/transinf.2013EDP7395.
Abstract: This paper provides a prototype neural prosthesis system dedicated to restoring continence and micturition function for patients with lower urinary tract diseases, such as detrusor hyperreflexia and detrusor-sphincter dyssynergia. This system consists of an ultra low-noise electroneurogram (ENG) signal recording module, a bi-phasic electrical stimulator module and a control unit for closed-loop bladder monitoring and controlling. In order to record extremely weak ENG signal from extradural sacral nerve roots, the system provides a programmable gain from 80 dB to 117 dB. By combining of advantages of commercial-off-the-shelf (COTS) electronics and custom designed IC, the recording front-end acquires a fairly low input-referred noise (IRN) of 0.69 μV_rms under 300 Hz to 3 kHz and high area-efficiency. An on-chip multi-steps single slope analog-to-digital converter (ADC) is used to digitize the ENG signals at sampling rate of 10 kSPS and achieves an effective number of bits (ENOB) of 12.5. A bi-phasic current stimulus generator with wide voltage supply range (±0.9 V to ±12.5 V) and variable output current amplitude (0-500 μA) is introduced to overcome patient-depended impedance between electrode and tissue electrolyte. The total power consumption of the entire system is 5.61 mW. Recording and stimulation function of this system is switched by control unit with time division multiplexing strategy. The functionality of this proposed prototype system has been successfully verified through in-vivo experiments from dogs extradural sacral nerve roots.
URL: https://global.ieice.org/en_transactions/information/10.1587/transinf.2013EDP7395/_p

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@ARTICLE{e97-d_10_2790,
author={Yuan WANG, Xu ZHANG, Ming LIU, Weihua PEI, Kaifeng WANG, Hongda CHEN, },
journal={IEICE TRANSACTIONS on Information},
title={An Implantable Sacral Nerve Root Recording and Stimulation System for Micturition Function Restoration},
year={2014},
volume={E97-D},
number={10},
pages={2790-2801},
abstract={This paper provides a prototype neural prosthesis system dedicated to restoring continence and micturition function for patients with lower urinary tract diseases, such as detrusor hyperreflexia and detrusor-sphincter dyssynergia. This system consists of an ultra low-noise electroneurogram (ENG) signal recording module, a bi-phasic electrical stimulator module and a control unit for closed-loop bladder monitoring and controlling. In order to record extremely weak ENG signal from extradural sacral nerve roots, the system provides a programmable gain from 80 dB to 117 dB. By combining of advantages of commercial-off-the-shelf (COTS) electronics and custom designed IC, the recording front-end acquires a fairly low input-referred noise (IRN) of 0.69 μV_rms under 300 Hz to 3 kHz and high area-efficiency. An on-chip multi-steps single slope analog-to-digital converter (ADC) is used to digitize the ENG signals at sampling rate of 10 kSPS and achieves an effective number of bits (ENOB) of 12.5. A bi-phasic current stimulus generator with wide voltage supply range (±0.9 V to ±12.5 V) and variable output current amplitude (0-500 μA) is introduced to overcome patient-depended impedance between electrode and tissue electrolyte. The total power consumption of the entire system is 5.61 mW. Recording and stimulation function of this system is switched by control unit with time division multiplexing strategy. The functionality of this proposed prototype system has been successfully verified through in-vivo experiments from dogs extradural sacral nerve roots.},
keywords={},
doi={10.1587/transinf.2013EDP7395},
ISSN={1745-1361},
month={October},}

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TY - JOUR
TI - An Implantable Sacral Nerve Root Recording and Stimulation System for Micturition Function Restoration
T2 - IEICE TRANSACTIONS on Information
SP - 2790
EP - 2801
AU - Yuan WANG
AU - Xu ZHANG
AU - Ming LIU
AU - Weihua PEI
AU - Kaifeng WANG
AU - Hongda CHEN
PY - 2014
DO - 10.1587/transinf.2013EDP7395
JO - IEICE TRANSACTIONS on Information
SN - 1745-1361
VL - E97-D
IS - 10
JA - IEICE TRANSACTIONS on Information
Y1 - October 2014
AB - This paper provides a prototype neural prosthesis system dedicated to restoring continence and micturition function for patients with lower urinary tract diseases, such as detrusor hyperreflexia and detrusor-sphincter dyssynergia. This system consists of an ultra low-noise electroneurogram (ENG) signal recording module, a bi-phasic electrical stimulator module and a control unit for closed-loop bladder monitoring and controlling. In order to record extremely weak ENG signal from extradural sacral nerve roots, the system provides a programmable gain from 80 dB to 117 dB. By combining of advantages of commercial-off-the-shelf (COTS) electronics and custom designed IC, the recording front-end acquires a fairly low input-referred noise (IRN) of 0.69 μV_rms under 300 Hz to 3 kHz and high area-efficiency. An on-chip multi-steps single slope analog-to-digital converter (ADC) is used to digitize the ENG signals at sampling rate of 10 kSPS and achieves an effective number of bits (ENOB) of 12.5. A bi-phasic current stimulus generator with wide voltage supply range (±0.9 V to ±12.5 V) and variable output current amplitude (0-500 μA) is introduced to overcome patient-depended impedance between electrode and tissue electrolyte. The total power consumption of the entire system is 5.61 mW. Recording and stimulation function of this system is switched by control unit with time division multiplexing strategy. The functionality of this proposed prototype system has been successfully verified through in-vivo experiments from dogs extradural sacral nerve roots.
ER -

IEICE TRANSACTIONS on Information