An output voltage estimation and regulation system for a wireless power transfer (WPT) circuit is proposed. Since the fluctuation of a coupling condition and/or a load may vary the voltage supplied with WPT resulting in a malfunction of wireless-powered devices, the output voltage regulation is needed. If the output voltage is regulated by a voltage regulator in a secondary side of the WPT circuit with fixed input power, the voltage regulator wastes the power to regulate the voltage. Therefore the output voltage regulation using a primary-side control, which adjusts the input power depending on the load and/or the coupling condition, is a promising approach for efficient regulation. In addition, it is desirable to eliminate feedback loop from the secondary side to the primary side from the viewpoint of reducing power dissipation and system complexity. The proposed system can estimate and regulate the output voltage independent of both the coupling and the load variation without the feedback loop. An usable range of the coupling coefficient and the load is improved compared to previous works. The validity of the proposed system is confirmed by the SPICE simulator.

This study focuses on the design of electrical stimulator for retinal prosthesis. The stimulator must be designed such that the occurrence of electrolysis or any irreversible process in the electrodes and flexible lead is prevented in order to achieve safe stimulation over long periods using the large number of electrodes. Some types of biphasic current pulse circuits, charge balance circuits, and AC power delivery circuits were developed to address this issue. Electronic circuitry must be introduced in the stimulator to achieve the large number of electrodes required to obtain high quality of vision. The concept of a smart electrode, in which a microchip is embedded inside an electrode, is presented for future retinal prostheses with over 1000 electrodes.

The brain-machine interface (BMI) is a new method for man-machine interface, which enables us to control machines and to communicate with others, without input devices but directly using brain signals. Previously, we successfully developed a real time control system for operating a robot arm using brain-machine interfaces based on the brain surface electrodes, with the purpose of restoring motor and communication functions in severely disabled people such as amyotrophic lateral sclerosis patients. A fully-implantable wireless system is indispensable for the clinical application of invasive BMI in order to reduce the risk of infection. This system includes many new technologies such as two 64-channel integrated analog amplifier chips, a Bluetooth wireless data transfer circuit, a wirelessly rechargeable battery, 3 dimensional tissue-fitting high density electrodes, a titanium head casing, and a fluorine polymer body casing. This paper describes key features of the first prototype of the BMI system for clinical application.

Effective countermeasures against explosive increase in healthcare expenditures are urgently needed. A paradigm shift in healthcare is called for, and academics and governments worldwide are working hard on the application of information and communication technologies (ICT) as a feasible and effective measure for reducing medical cost. The more prevalent the disease and the easier disease outcome can be improved, the more efficient is medical ICT in reducing healthcare cost. Hypertension and diabetes mellitus are such examples. Chronic heart failure is another disease in which patients may benefit from ICT-based medical practice. It is conceivable that daily monitoring of hemodynamics together with appropriate treatments may obviate the expensive hospitalization. ICT potentially permit continuous monitoring with wearable or implantable medical devices. ICT may also help accelerate the development of new therapeutic devices. Traditionally effectiveness of treatments is sequentially examined by sacrificing a number of animals at a given time point. These inefficient and inaccurate methods can be replaced by applying ICT to the devices used in chronic animal experiments. These devices allow researchers to obtain biosignals and images from live animals without killing them. They include implantable telemetric devices, implantable telestimulation devices, and imaging devices. Implanted rather than wired monitoring and stimulation devices permit experiments to be conducted under even more physiological conditions, i.e., untethered, free-moving states. Wireless communication and ICT are indispensible technologies for the development of such telemetric and telestimulation devices.