Accurate segmentation of fundus vessel structure can effectively assist doctors in diagnosing eye diseases. In this paper, we propose a fundus blood vessel segmentation network combined with cross-modal features and verify our method on the public data set OCTA-500. Experimental results show that our method has high accuracy and robustness.

Clinical researches show that the morbidity of coronary artery disease (CAD) is gradually increasing in many countries every year, and it causes hundreds of thousands of people all over the world dying for each year. As the optical coherence tomography with high resolution and better contrast applied to the lesion tissue investigation of human vessel, many more micro-structures of the vessel could be easily and clearly visible to doctors, which help to improve the CAD treatment effect. Manual qualitative analysis and classification of vessel lesion tissue are time-consuming to doctors because a single-time intravascular optical coherence (IVOCT) data set of a patient usually contains hundreds of in-vivo vessel images. To overcome this problem, we focus on the investigation of the superficial layer of the lesion region and propose a model based on local multi-layer region for vessel lesion components (lipid, fibrous and calcified plaque) features characterization and extraction. At the pre-processing stage, we applied two novel automatic methods to remove the catheter and guide-wire respectively. Based on the detected lumen boundary, the multi-layer model in the proximity lumen boundary region (PLBR) was built. In the multi-layer model, features extracted from the A-line sub-region (ALSR) of each layer was employed to characterize the type of the tissue existing in the ALSR. We used 7 human datasets containing total 490 OCT images to assess our tissue classification method. Validation was obtained by comparing the manual assessment with the automatic results derived by our method. The proposed automatic tissue classification method achieved an average accuracy of 89.53%, 93.81% and 91.78% for fibrous, calcified and lipid plaque respectively.

A novel image enhancement method for vein recognition is introduced. Inspired by observation that the intensity of the vein vessel changes rapidly during the smoothing process compared to that of background (i.e., skin tissue) due to its thin and long shape, we propose to exploit the smoothing speed as a restoration weight for the vein image enhancement. Experimental results based on the CASIA multispectral palm vein database demonstrate that the proposed method is effective to improve the performance of vein recognition.

Precise estimation of coronary arteries from computed tomography angiography (CTA) data is one of the challenging problems. This study focuses on automatic delineation of coronary arteries from 3D CTA data that may assess the clinicians in identifying the coronary pathologies. In this work, we present a technique that effectively segments the complete coronary arterial tree under the guidance of initial vesselness response without relying on heavily manual operations. The proposed method isolates the coronary arteries with accuracy by using localized statistical energy model in two directions provided with an automated seed which ensures an optimal segmentation of the coronaries. The detection of seed is carried out by analyzing the shape information of the coronary arteries in three successive cross-sections. To demonstrate the efficiency of the proposed algorithm, the obtained results are compared with the reference data provided by Rotterdam framework for lumen segmentation and the level-set active contour based method proposed by Lankton et al. Results reveal that the proposed method performs better in terms of leakages and accuracy in completeness of the coronary arterial tree.

In retinal blood vessel extraction through background removal, the vessels in a fundus image which appear in a higher illumination variance area are often missing after the background is removed. This is because the intensity values of the vessel and the background are nearly the same. Thus, the estimated background should be robust to changes of the illumination intensity. This paper proposes retinal blood vessel extraction using background estimation. The estimated background is calculated by using a weight surface fitting method with a high degree polynomial. Bright pixels are defined as unwanted data and are set as zero in a weight matrix. To fit a retinal surface with a higher degree polynomial, fundus images are reduced in size by different scaling parameters in order to reduce the processing time and complexity in calculation. The estimated background is then removed from the original image. The candidate vessel pixels are extracted from the image by using the local threshold values. To identify the true vessel region, the candidate vessel pixels are dilated from the candidate. After that, the active contour without edge method is applied. The experimental results show that the efficiency of the proposed method is higher than the conventional low-pass filter and the conventional surface fitting method. Moreover, rescaling an image down using the scaling parameter at 0.25 before background estimation provides as good a result as a non-rescaled image does. The correlation value between the non-rescaled image and the rescaled image is 0.99. The results of the proposed method in the sensitivity, the specificity, the accuracy, the area under the receiver operating characteristic (ROC) curve (AUC) and the processing time per image are 0.7994, 0.9717, 0.9543, 0.9676 and 1.8320 seconds for the DRIVE database respectively.

Since retina blood vessels (RBV) are a major factor in ophthalmological diagnosis, it is essential to detect RBV from a fundus image. In this letter, we proposed the detection method of RBV using a morphological analysis and support vector machine classification. The proposed RBV detection method consists of three strategies: pre-processing, features extraction and classification. In pre-processing, noises were reduced and RBV were enhanced by anisotropic diffusion filtering and illumination equalization. Features were extracted by using the image intensity and morphology of RBV. And a support vector machine (SVM) classification algorithm was used to detect RBV. The proposed RBV detection method was simulated and validated by using the DRIVE database. The averages of accuracy and TPR are 0.94 and 0.78, respectively. Moreover, by comparison, we confirmed that the proposed RBV detection method detected RBV better than the recent RBV detections methods.

A new method to extract retinal blood vessels from a colour fundus image is described. Digital colour fundus images are contrast enhanced in order to obtain sharp edges. The green bands are selected and transformed to correlation coefficient images by using two sets of Gaussian kernel patches of distinct scales of resolution. Blood vessels are then extracted by means of a new algorithm, directional recursive region growing segmentation or D-RRGS. The segmentation results have been compared with clinically-generated ground truth and evaluated in terms of sensitivity and specificity. The results are encouraging and will be used for further application such as blood vessel diameter measurement.

The conventional method requires a centerline of a vessel to estimate the vessel diameter. Two methods of estimating the centerline of vessels have been reported: One is to manually define the centerline of the vessel. This potentially contributes to inter- and intra-observer variability. The orientation of the centerline has an effect on the diameter function since diameters are computed perpendicular to the centerline. And the other is to automatically detect the centerline of the vessel. But this is a very complicated method. In this paper, we propose a new method of estimating vessel diameter using direction codes without detecting centerline. Since this method detects the vessel boundary and direction code at the same time, it simplifies the procedure and reduces execution time in estimating the vessel diameter. Compared to a method that automatically estimates the vessel diameter using centerline, a proposed method provides an improved accuracy in image with poor contrast, branching or obstructed vessels. Also, this provides a good compression of boundary description. Our experiments demonstrate the usefulness of the technique using direction code for quantitative angiography. Experimental results justify the validity of the proposed method.