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IEICE TRANSACTIONS on Electronics

Open Access
Design of CMOS Circuits for Electrophysiology

Nick VAN HELLEPUTTE, Carolina MORA-LOPEZ, Chris VAN HOOF

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Summary :

Electrophysiology, which is the study of the electrical properties of biological tissues and cells, has become indispensable in modern clinical research, diagnostics, disease monitoring and therapeutics. In this paper we present a brief history of this discipline and how integrated circuit design shaped electrophysiology in the last few decades. We will discuss how biopotential amplifier design has evolved from the classical three-opamp architecture to more advanced high-performance circuits enabling long-term wearable monitoring of the autonomous and central nervous system. We will also discuss how these integrated circuits evolved to measure in-vivo neural circuits. This paper targets readers who are new to the domain of biopotential recording and want to get a brief historical overview and get up to speed on the main circuit design concepts for both wearable and in-vivo biopotential recording.

Publication
IEICE TRANSACTIONS on Electronics Vol.E106-C No.10 pp.506-515
Publication Date
2023/10/01
Publicized
2023/07/11
Online ISSN
1745-1353
DOI
10.1587/transele.2022CTI0003
Type of Manuscript
Special Section INVITED PAPER (Special Section on Analog Circuits and Their Application Technologies)
Category

Authors

Nick VAN HELLEPUTTE
  imec
Carolina MORA-LOPEZ
  imec
Chris VAN HOOF
  imec,KU Leuven

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