Electrophysiology, which is the study of the electrical properties of biological tissues and cells, has become indispensable in modern clinical research, diagnostics, disease monitoring and therapeutics. In this paper we present a brief history of this discipline and how integrated circuit design shaped electrophysiology in the last few decades. We will discuss how biopotential amplifier design has evolved from the classical three-opamp architecture to more advanced high-performance circuits enabling long-term wearable monitoring of the autonomous and central nervous system. We will also discuss how these integrated circuits evolved to measure in-vivo neural circuits. This paper targets readers who are new to the domain of biopotential recording and want to get a brief historical overview and get up to speed on the main circuit design concepts for both wearable and in-vivo biopotential recording.

Recently, the ECG-based diagnosis system based on wearable devices has attracted more and more attention of researchers. Existing studies have achieved high classification accuracy by using deep neural networks (DNNs), but there are still some problems, such as: imprecise heart beat segmentation, inadequate use of medical knowledge, the same treatment of features with different importance. To address these problems, this paper: 1) proposes an adaptive segmenting-reshaping method to acquire abundant useful samples; 2) builds a set of hand-crafted features and deep features on the inner-beat, beat and inter-beat scale by integrating enough medical knowledge. 3) introduced a modified channel attention module (CAM) to augment the significant channels in deep features. Following the Association for Advancement of Medical Instrumentation (AAMI) recommendation, we classified the dataset into four classes and validated our algorithm on the MIT-BIH database. Experiments show that the accuracy of our model reaches 96.94%, a 3.71% increase over that of a state-of-the-art alternative.

Hum noise such as power line interference is one of the critical problems in the biomedical signal acquisition. Various techniques have been proposed to suppress power line interference. However, some of the techniques require more components and power consumption. The notch depth in the conventional N-path notch filter circuits needs a higher number of paths and switches off-resistance. It makes the conventional N-path notch filter less of efficiency to suppress hum noise. This work proposed the new N-path notch filter to hum noise suppression in biomedical signal acquisition. The new N-path notch filter achieved notch depth above 40dB with sampling frequency 50Hz and 60Hz. Although the proposed circuits use less number of path and switches off-resistance. The proposed circuit has been verified using artificial ECG signal contaminated by hum noise at frequency 50Hz and 60Hz. The output of N-path notch filter achieved a noise-free signal even if the sampling frequency changes.

This paper presents an automated patient-specific ECG classification algorithm, which integrates long short-term memory (LSTM) and convolutional neural networks (CNN). While LSTM extracts the temporal features, such as the heart rate variance (HRV) and beat-to-beat correlation from sequential heartbeats, CNN captures detailed morphological characteristics of the current heartbeat. To further improve the classification performance, adaptive segmentation and re-sampling are applied to align the heartbeats of different patients with various heart rates. In addition, a novel clustering method is proposed to identify the most representative patterns from the common training data. Evaluated on the MIT-BIH arrhythmia database, our algorithm shows the superior accuracy for both ventricular ectopic beats (VEB) and supraventricular ectopic beats (SVEB) recognition. In particular, the sensitivity and positive predictive rate for SVEB increase by more than 8.2% and 8.8%, respectively, compared with the prior works. Since our patient-specific classification does not require manual feature extraction, it is potentially applicable to embedded devices for automatic and accurate arrhythmia monitoring.

Objective: Detection of Electrocardiogram (ECG) characteristic points can provide critical diagnostic information about heart diseases. We proposed a novel feature extraction and machine learning scheme for automatic detection of ECG characteristic points. Methods: A new feature, termed as randomly selected wavelet transform (RSWT) feature, was devised to represent ECG characteristic points. A random forest classifier was adapted to infer the characteristic points position with high sensitivity and precision. Results: Compared with other state-of-the-art algorithms' testing results on QT database, our detection results of RSWT scheme showed comparable performance (similar sensitivity, precision, and detection error for each characteristic point). RSWT testing on MIT-BIH database also demonstrated promising cross-database performance. Conclusion: A novel RSWT feature and a new detection scheme was fabricated for ECG characteristic points. The RSWT demonstrated a robust and trustworthy feature for representing ECG morphologies. Significance: With the effectiveness of the proposed RSWT feature we presented a novel machine learning based scheme to automatically detect all types of ECG characteristic points at a time. Furthermore, it showed that our algorithm achieved better performance than other reported machine learning based methods.

Automatic detection of heart cycle abnormalities in a long duration of ECG data is a crucial technique for diagnosing an early stage of heart diseases. Concretely, Paroxysmal stage of Atrial Fibrillation rhythms (ParAF) must be discriminated from Normal Sinus rhythms (NS). The both of waveforms in ECG data are very similar, and thus it is difficult to completely detect the Paroxysmal stage of Atrial Fibrillation rhythms. Previous studies have tried to solve this issue and some of them achieved the discrimination with a high degree of accuracy. However, the accuracies of them do not reach 100%. In addition, no research has achieved it in a long duration, e.g. 12 hours, of ECG data. In this study, a new mechanism to tackle with these issues is proposed: “Door-to-Door” algorithm is introduced to accurately and quickly detect significant peaks of heart cycle in 12 hours of ECG data and to discriminate obvious ParAF rhythms from NS rhythms. In addition, a quantitative method using Artificial Neural Network (ANN), which discriminates unobvious ParAF rhythms from NS rhythms, is investigated. As the result of Door-to-Door algorithm performance evaluation, it was revealed that Door-to-Door algorithm achieves the accuracy of 100% in detecting the significant peaks of heart cycle in 17 NS ECG data. In addition, it was verified that ANN-based method achieves the accuracy of 100% in discriminating the Paroxysmal stage of 15 Atrial Fibrillation data from 17 NS data. Furthermore, it was confirmed that the computational time to perform the proposed mechanism is less than the half of the previous study. From these achievements, it is concluded that the proposed mechanism can practically be used to diagnose early stage of heart diseases.

Arrhythmia classification based on electrocardiogram (ECG) is crucial in automatic cardiovascular disease diagnosis. The classification methods used in the current practice largely depend on hand-crafted manual features. However, extracting hand-crafted manual features may introduce significant computational complexity, especially in the transform domains. In this study, an accurate method for patient-specific ECG beat classification is proposed, which adopts morphological features and timing information. As to the morphological features of heartbeat, an attention-based two-level 1-D CNN is incorporated in the proposed method to extract different grained features automatically by focusing on various parts of a heartbeat. As to the timing information, the difference between previous and post RR intervels is computed as a dynamic feature. Both the extracted morphological features and the interval difference are used by multi-layer perceptron (MLP) for classifing ECG signals. In addition, to reduce memory storage of ECG data and denoise to some extent, an adaptive heartbeat normalization technique is adopted which includes amplitude unification, resolution modification, and signal difference. Based on the MIT-BIH arrhythmia database, the proposed classification method achieved sensitivity Sen=93.4% and positive predictivity Ppr=94.9% in ventricular ectopic beat (VEB) detection, sensitivity Sen=86.3% and positive predictivity Ppr=80.0% in supraventricular ectopic beat (SVEB) detection, and overall accuracy OA=97.8% under 6-bit ECG signal resolution. Compared with the state-of-the-art automatic ECG classification methods, these results show that the proposed method acquires comparable accuracy of heartbeat classification though ECG signals are represented by lower resolution.

This work presents a low-complexity lossless electrocardiogram (ECG) compression ASIC for wireless sensors. Three linear predictors aiming for different signal characteristics are provided for prediction based on a history table that records of the optimum predictors for recent samples. And unlike traditional methods using a unified encoder, the prediction error is encoded by a hybrid Golomb encoder combining Exp-Golomb and Golomb-Rice and can adaptively configure the encoding scheme according to the predictor selection. The novel adaptive prediction and encoding scheme contributes to a compression rate of 2.77 for the MIT-BIH Arrhythmia database. Implemented in 40nm CMOS process, the design takes a small gate count of 1.82K with 37.6nW power consumption under 0.9V supply voltage.

In wireless telecardiology applications, electrocardiogram (ECG) signals are often represented in compressed format for efficient transmission and storage purposes. Incorporation of compressed ECG based biometric enables faster person identification as it by-passes the full decompression. This study presents a new method to combine ECG biometrics with data compression within a common JPEG2000 framework. To this end, an ECG signal is considered as an image and the JPEG2000 standard is applied for data compression. Features relating to ECG morphology and heartbeat intervals are computed directly from the compressed ECG. Different classification approaches are used for person identification. Experiments on standard ECG databases demonstrate the validity of the proposed system for biometric identification with high accuracies on both healthy and diseased subjects.

In this study, we propose a two-step approach to evaluate electromagnetic interference (EMI) with a wearable vital signal sensor. The two-step approach combines a quasi-static electromagnetic (EM) field analysis and an electric circuit analysis, and is applied to the EMI evaluation at frequencies below 1 MHz for our developed wearable electrocardiogram (ECG) to demonstrate its usefulness. The quasi-static EM field analysis gives the common mode voltage coupled from the incident EM field at the ECG sensing electrodes, and the electric circuit analysis quantifies a differential mode voltage at the differential amplifier output of the ECG detection circuit. The differential mode voltage has been shown to come from a conversion from the common mode voltage due to an imbalance between the contact impedances of the two sensing electrodes. When the contact impedance is resistive, the induced differential mode voltage increases with frequency up to 100kHz, and keeps constant after 100kHz, i.e., exhibits a high pass filter characteristic. While when the contact impedance is capacitive, the differential mode voltage exhibits a band pass filter characteristic with the maximum at frequency of around 150kHz. The differential voltage may achieve nearly 1V at the differential amplifier output for an imbalance of 30% under 10V/m plane-wave incident electric field, and completely mask the ECG signal. It is essential to reduce the imbalance as much as possible so as to prevent a significant interference voltage in the amplified ECG signal.

Wireless patient monitoring is an active research area with the goal of ubiquitous health care services. This study presents a novel means of exploiting the distributed source coding (DSC) in low-complexity compression of ECG signals. We first convert the ECG data compression to an equivalent channel coding problem and exploit a linear channel code for the DSC construction. Performance is further enhanced by the use of a correlation channel that more precisely characterizes the statistical dependencies of ECG signals. Also proposed is a modified BCJR algorithm which performs symbol decoding of binary convolutional codes to better exploit the source's a priori information. Finally, a complete setup system for online ambulatory ECG monitoring via mobile cellular networks is presented. Experiments on the MIT-BIH arrhythmia database and real-time acquired ECG signals demonstrate that the proposed system outperforms other schemes in terms of encoder complexity and coding efficiency.

A reliable detection of atrial fibrillation (AF) in Electrocardiogram (ECG) monitoring systems is significant for early treatment and health risk reduction. Various ECG mining and analysis studies have addressed a wide variety of clinical and technical issues. However, there is still room for improvement mostly in two areas. First, the morphological descriptors not only between different patients or patient clusters but also within the same patient are potentially changing. As a result, the model constructed using an old training data no longer needs to be adjusted in order to identify new concepts. Second, the number and types of ECG parameters necessary for detecting AF arrhythmia with high quality encounter a massive number of challenges in relation to computational effort and time consumption. We proposed a mixture technique that caters to these limitations. It includes an active learning method in conjunction with an ECG parameter customization technique to achieve a better AF arrhythmia detection in real-time applications. The performance of our proposed technique showed a sensitivity of 95.2%, a specificity of 99.6%, and an overall accuracy of 99.2%.

This paper presents a new dimension in e-learning by collecting and analyzing physiological data during real-world e-learning sessions. Two different content materials, namely Interactive (IM) and Non-interactive (N-IM), were utilized to determine the physiological state of e-learners. Electrocardiogram (ECG) and Skin Conductance Level (SCL) were recorded continuously while learners experienced IM and N-IM for about 25 minutes each. Data from 18 students were collected for analysis. As a result significant difference between IM and N-IM was observed in SCL (p <.01) meanwhile there were no significance in other indices such as heart rate and its variability, and skin conductance response (SCR). This study suggests a new path in understanding e-learners' physiological state with regard to different e-learning materials; the results of this study suggest a clear distinction in physiological states in the context of different learning materials.

This paper proposes a joint source-channel coding technology to transmit periodic vital information such as an electrocardiogram. There is an urgent need for a ubiquitous medical treatment space in which personalized medical treatment is automatically provided based on measured vital information. To realize such treatment and reduce the constraints on the patient, wireless transmission of vital information from a sensor device to a data aggregator is essential. However, the vital information has to be correctly conveyed through wireless channels. In addition, sensor devices are constrained by their battery power. Thus, a coding technique that provides robustness to noise, channel efficiency and low power consumption at encoding is essential. This paper presents a coding method that uses correlation of periodic vital information in the time domain, and provides a decoding scheme that uses the correlation as side information in a maximum a posteriori probability algorithm. Our results show that the proposed method provides better performance in terms of mean squared error after decoding in comparison to differential pulse-code modulation, and the uncoded case.

The heart rate variability (HRV) is a measure based on the time position of the electrocardiogram (ECG) R-waves. There is a discussion whether or not we can obtain the HRV pattern from blood pressure (BP). In this paper, we propose a method for estimating HRV from a BP signal based on a HIF algorithm and carrying out experiments to compare BP as an alternative measurement of ECG to calculate HRV. Based on the hypotheses that ECG and BP have the same harmonic behavior, we model an alternative HRV signal using a nonlinear algorithm, called heart instantaneous frequency (HIF). It tracks the instantaneous frequency through a rough fundamental frequency using power spectral density (PSD). A novelty in this work is to use fundamental frequency instead of wave-peaks as a parameter to estimate and quantify beat-to-beat heart rate variability from BP waveforms. To verify how the estimate HRV signals derived from BP using HIF correlates to the standard gold measures, i.e. HRV derived from ECG, we use a traditional algorithm based on QRS detectors followed by thresholding to localize the R-wave time peak. The results show the following: 1) The spectral error caused by misestimation of time by R-peak detectors is demonstrated by an increase in high-frequency bands followed by the loss of time domain pattern. 2) The HIF was shown to be robust against noise and nuisances. 3) By using statistical methods and nonlinear analysis no difference between HIF derived from BP and HRV derived from ECG was observed.

In order for the interconnect effects due to process-induced variations to be applied to the designs in 0.13 µm and below, it is necessary to determine and characterize the realistic interconnect worstcase models with high accuracy and speed. This paper proposes new statistically-based approaches to the characterization of realistic interconnect worstcase models which take into account process-induced variations. The Effective Common Geometry (ECG) and Accumulated Maximum Probability (AMP) algorithms have been developed and implemented into the new statistical interconnect worstcase design environment. To verify this statistical interconnect worstcase design environment, the 31-stage ring oscillators are fabricated and measured with UMC 0.13 µm Logic process. The 15-stage ring oscillators are fabricated and measured with 0.18 µm standard CMOS process for investigating its flexibility in other technologies. The results show that the relative errors of the new method are less than 1.00%, which is two times more accurate than the conventional worstcase method. Furthermore, the new interconnect worstcase design environment improves optimization speed by 29.61-32.01% compared to that of the conventional worstcase optimization. The new statistical interconnect worstcase design environment accurately predicts the worstcase and bestcase corners of non-normal distribution where conventional methods cannot do well.

We propose a new approach to personal identification using derived vectorcardiogram (dVCG). The dVCG was calculated from recorded ECG using inverse Dower transform. Twenty-one features were extracted from the resulting dVCG. To analyze the effect of each feature and to improve efficiency while maintaining the performance, we performed feature selection using the Relief-F algorithm using these 21 features. Each set of the eight highest ranked features and all 21 features were used in SVM learning and in tests, respectively. The classification accuracy using the entire feature set was 99.53 %. However, using only the eight highest ranked features, the classification accuracy was 99.07 %, indicating only a 0.46 % decrease in accuracy compared with the accuracy achieved using the entire feature set. Using only the eight highest ranked features, the conventional ECG method resulted in a 93 % recognition rate, whereas our method achieved >99 % recognition rate, over 6 % higher than the conventional ECG method. Our experiments show that it is possible to perform a personal identification using only eight features extracted from the dVCG.

Fetal electrocardiogram (FECG) extraction is of vital importance in biomedical signal processing. A promising approach is blind source extraction (BSE) emerging from the neural network fields, which is generally implemented in a semi-blind way. In this paper, we propose a robust extraction algorithm that can extract the clear FECG as the first extracted signal. The algorithm exploits the fact that the FECG signal's kurtosis value lies in a specific range, while the kurtosis values of other unwanted signals do not belong to this range. Moreover, the algorithm is very robust to outliers and its robustness is theoretically analyzed and is confirmed by simulation. In addition, the algorithm can work well in some adverse situations when the kurtosis values of some source signals are very close to each other. The above reasons mean that the algorithm is an appealing method which obtains an accurate and reliable FECG.

This study proposed the new method to minimize distortion of the ST segment and noise deletion of ECG baseline wander. In general, the standard filter and adaptive filter are used to remove the baseline wander of the ECG. The standard filter, however, is limited because the frequency of the baseline signal is variable and the baseline wander's spectrum overlaps with the ST segment's spectrum, and for the adaptive filter, it is difficult to select the reference signal. This study proposed a new, structured adaptive filter that is to remove noise without reference signal using neural networks. In order to confirm performance, this paper used ECG data of MIT-BIHs and obtained significant results through the tests.

A quasi-periodic signal is a periodic signal with period and amplitude variations. Several physiological signals, including the electrocardiogram (ECG), can be treated as quasi-periodic. Vector quantization (VQ) is a valuable and universal tool for signal compression. However, compressing quasi-periodic signals using VQ presents several problems. First, a pre-trained codebook has little adaptation to signal variations, resulting in no quality control of reconstructed signals. Secondly, the periodicity of the signal causes data redundancy in the codebook, where many codevectors are highly correlated. These two problems are solved by the proposed codebook replenishment VQ (CRVQ) scheme based on a bar-shaped (BS) codebook structure. In the CRVQ, codevectors can be updated online according to signal variations, and the quality of reconstructed signals can be specified. With the BS codebook structure, the codebook redundancy is reduced significantly and great codebook storage space is saved; moreover variable-dimension (VD) codevectors can be used to minimize the coding bit rate subject to a distortion constraint. The theoretic rationale and implementation scheme of the VD-CRVQ is given. The ECG data from the MIT/BIH arrhythmic database are tested, and the result is substantially better than that of using other VQ compression methods.