Well-defined wavelength distributed feedback laser diodes (DFB-LDs) are required in WDM network systems. Since the EDFA gain bands have been expanded, even more wavelengths are needed for large-capacity dense-WDM transmission systems. A precisely pitch-controlled Bragg grating fabricated by electron beam (EB) lithography is very attractive for realizing these DFB-LDs. This paper describes this precise pitch- and phase-controlled grating delineated by a novel method called weighted-dose allocation variable-pitch EB-lithography (WAVE). In this method, an EB-dose profile for the grating is precisely controlled by a combination of the allocation and weighting of multiple exposures. This enables us to fabricate a precise fixed-pitch grating as well as a flexible grating with a continuously chirped structure. The stitching error at the exposure field boundary, the grating pitch, and the phase shift were evaluated by using a moire pattern generated by superimposing the microscope raster scan and the grating on a wafer. We also estimated amounts of the stitching errors from fabricated and calculated lasing characteristics, and clarified that the affect of the errors on the single-mode stability of LDs is negligible. Precise wavelength controlled λ/4 phase shifted DFB-LDs were successfully demonstrated as a result of both the WAVE method and the highly uniform MOVPE crystal growth.

Scientific database systems for the analysis of genes and proteins are becoming very important these days. We have developed a deductive database system PACADE for analyzing the three dimensional and secondary structures of proteins. In this paper, we describe the statistical data classification component of PACADE. We implemented the component for cluster analysis and discrimination analysis. In addition, we enhanced the aggregation function in order to calculate the characteristic values which are useful for data classification. By using the cluster analysis function, the proteins are thereby classified into different types of structural characteristics. The results of these structural analysis experiments are also described in this paper.

Intensity-noise characteristics of stable multi-mode Fabry-Perot semiconductor lasers are analyzed experimentally and theoretically. Mode-partition noise caused by optical filtering and propagation through optical fibers is investigated by evaluating the relative intensity noise and signal-to-noise ratio. The experimental results indicate that the simplified two-mode analysis provides a good approximation. Suppression of the mode-partition noise by nonlinear gain is experimentally confirmed.

A theoretical study on high slope-efficiency phase-shifted DFB laser diodes is presented. We have proposed a new grating structure called asymmetrically-pitch-modulated (APM) grating, and calculated its slope- efficiency and single-mode-yield. In order to take into account the modulated grating period; we have developed an F-matrix which directly includes a chirped grating structure. APM phase-shifted DFB laser diodes consist of a uniform grating in one half section of the cavity and a chirped grating in the other half. This structure causes asymmetrical field distribution inside the cavity and the optical output power from one facet is larger than that from the other facet. According to the simulation results, when the normalized coupling coefficient κ L is 3.0, the front-to-rear output power ratio is 2.6, while the single-mode-yield remains at 100%, and simultaneously the slope-efficiency improvement becomes 65% better than that of ordinary quarter-wave phase-shifted DFB lasers of the same κ L value.

Microarray technology has been applied to various biological and medical research fields. A preliminary step to extract any information from a microarray data set is to identify differentially expressed genes between microarray data. The identification of the differentially expressed genes and their commonly associated GO terms allows us to find stimulation-dependent or disease-related genes and biological events, etc. However, the identification of these deregulated GO terms by general approaches including gene set enrichment analysis (GSEA) does not necessarily provide us with overrepresented GO terms in specific data among a microarray data set (i.e., data-specific GO terms). In this paper, we propose a statistical method to correctly identify the data-specific GO terms, and estimate its availability by simulation using an actual microarray data set.

We present low-cost millimeter-wave (MMW) photonic techniques for implementing gigabit/s wireless links. A passive mode-locked laser consisting of a Fabry-Perot laser and a single-mode fiber is used to generate 120-GHz optical MMW signals. We modulated these MMW signals by controlling the bias voltage of the photodiode. The MMW generation and modulation methods do not need expensive photonic components or high-power drivers. A link employing these low-cost photonic techniques achieved 1.25-Gbit/s wireless data transmission.

Novel gain monitoring scheme in Remotely-Pumped EDF/DRA hybrid inline amplifier is proposed using Optical Time Domain Reflectometer (OTDR). Signal degradation due to cross gain modulation (XGM) caused by an OTDR pulse in the distributed Raman amplifier (DRA) section and remotely-pumped EDF (RP-EDF) unit is analyzed theoretically. The required conditions for suppressing of XGM in the DRA section are derived. We propose the directional bypass configuration to realize OTDR measurement without XGM in the EDF unit. Transmission experiments using the RP-EDF/DRA hybrid inline amplifier demonstrate the absence of transmission impairement induced by OTDR. An analysis of the OTDR trace for each gain medium is also discussed. The theoretical analysis agrees well with the experimental result.

This paper describes short pulse generation at over 40 GHz using monolithic mode-locked lasers integrated with electroabsorption modulators. The electroabsorption modulator using strained-InGaAsP multiquantum wells provides a pulse shortening gate at a high-repetition frequency. Pulse generation around 4 ps has been realized at a repetition frequency of 43. 5 GHz. Pulse compression using a 1. 3 µm single mode fiber is performed and a 0. 87 ps pulse is obtained.

The first results of a field trial held in November 2000, of 1 Tbit/s (25 43 Gbit/s) unidirectional Wavelength Division Multiplexing (WDM) transmission, are presented. The field trial used a 43 Gbit/s/channel Optical Transport Network (OTN) interface prototype and standard Single Mode Fibers (SMFs) installed in the Nara area network of NTT West Corporation. The features of this field trial include the accommodation of multiple services such as GbE, STM-16 and OC-48. Error free operation of 25 channels with 100 GHz spacing over a 91 km standard SMF with Forward Error Correction (FEC) is verified for STM-16. A DV stream over IP over Ethernet as a tributary channel was also successfully transmitted.

Pure green ZnTe light-emitting diodes (LEDs) were first realized reproducibly based on high quality ZnTe substrates and a simple thermal diffusion process. This success which overcomes the compensation effect in II-VI materials is due to the use of high quality p-type ZnTe single crystals with low dislocation densities of the level of 2000 cm-2 grown by the vertical gradient freezing (VGF) method and the suppression of as compensating point defects by low temperature annealing with covering the surface of the substrates by the deposition of n-type dopant, Al. The thermal diffusion coefficient and the activation energy of Al were determined from the pn interface observed by scanning electron spectroscopy (SEM). The formation of the intrinsic pn junctions was confirmed from the electron-beam induced current (EBIC) observation and I-V measurement. The bright 550 nm electroluminescence (EL) from these pn-junctions was reproducibly observed under room light at room temperature, with the lifetime exceeding 1000 hrs.

A new device consisting of an optical pulse generation section and pulse coding section monolithically integrated on a single-chip has been developed. The pulse generation section consists of a multiple quantum well (MQW) electroabsorption modulator integrated with an MQW DFB laser. The modulator operates at large-signal modulation and low voltage (from 2 to 3-V DC bias with a 3.2-V peak-to-peak RF signal). The second modulator is operated independently as a pulse encoder. An approximately transform-limited optical pulse train, whose full width at half maximum (FWHM) in the time domain is less than 17-ps and spectral FWHM is 28-GHz, is obtained with a repetition frequency of 10-GHz. Compressive strain is introduced in both InGaAsP quantum wells in order to obtain efficient device characteristics. These include a low threshold current (18-mA) for the laser, and low driving voltage (30-dB for 3-V swing) and high-speed operation (over 12-GHz for a 3-dB bandwidth) for the modulators. Demonstrations show that this new device generates short optical pulses encoded by a pseudo-random signal at a rate of 10 Gbit/s. This is the first time 10 Gbit/s modulation has been achieved with a multi-section electroabsorption modulator/DFB laser integrated light source. This monolithic device is expected to be applied to optical soliton transmitters.

We achieved a dispersion tolerance of 25-ps/nm at 80-Gbit/s using novel carrier-suppressed return-to-zero (CS-RZ) coding realized by duty ratio and optical multiplexing phase control. We also show that the dispersion tolerance strongly depends on the relative optical phase difference between adjacent time slots, and demonstrate 80-Gbit/s 60-km DSF transmission without dispersion compensation by using a newly-fabricated stable 80-Gbit/s OTDM transmitter.

Phase-inversion between neighboring pulses appearing in carrier-suppressed return-to-zero pulses is effective in reducing the signal distortion due to chromatic dispersion and nonlinear effects. A generation method of the anti-phase pulses at 40 GHz is demonstrated by using semiconductor mode-locked lasers integrated with chirped gratings. Operation principle and pulse characteristics are described. Suppression of pulse distortion due to fiber dispersion is confirmed for generated anti-phase pulses. Repeaterless 150-km dispersion-shifted-fiber L-band transmission at 42.7 Gbit/s is demonstrated by using the pulse source.

One kind of functional noncoding RNAs, microRNAs (miRNAs), form a class of endogenous RNAs that can have important regulatory roles in animals and plants by targeting transcripts for cleavage or translation repression. Researches on both experimental and computational approaches have shown that miRNAs indeed involve in the human cancer development and progression. However, the miRNAs that contribute more information to the distinction between the normal and tumor samples (tissues) are still undetermined. Recently, the high-throughput microarray technology was used as a powerful technique to measure the expression level of miRNAs in cells. Analyzing this expression data can allow us to determine the functional roles of miRNAs in the living cells. In this paper, we present a computational method to (1) predicting the tumor tissues using high-throughput miRNA expression profiles; (2) finding the informative miRNAs that show strong distinction of expression level in tumor tissues. To this end, we perform a support vector machine (SVM) based method to deeply examine one recent miRNA expression dataset. The experimental results show that SVM-based method outperforms other supervised learning methods such as decision trees, Bayesian networks, and backpropagation neural networks. Furthermore, by using the miRNA-target information and Gene Ontology annotations, we showed that the informative miRNAs have strong evidences related to some types of human cancer including breast, lung, and colon cancer.