We applied control theory to nerve-muscle in order to model and systematize the muscle system. The association between nerve stimulation frequencies and electromyogram (EMG) amplitude was studied in rat nerve-muscle under normal and hypokalemic conditions. From these results, we modeled the nerve-muscle and simulated frequency response from the nerve-muscle system which can be expressed as a closed loop transfer function.

Space-variant approaches subject to local image characteristics are useful in practical image restoration because many natural images are nonstationary. Motivated by the success of denoising approaches in the wavelet domain, we propose a region-adaptive restoration approach which adopts a wavelet denoising technique in flat regions after an under-regularized constrained least squares restoration. Experimental results verify that this approach not only improves image quality in mean square error but also contributes to ringing reduction.

This study attempts to demonstrate that activated leukocytes are involved in vascular shut down effect (VSD) in photodynamic therapy (PDT). Hydrogen peroxide (H2O2), a reactive oxygen specie (ROS) that is found in monocytes, was visualized under a confocal laser scanning microscope, and ROS formation was quantified by fluorescence image analysis. The fluorescence intensity was expressed as a gray level graded from 0 to 255. Only the fluorescence derived from monocytes that had ZnCP-III incorporated and were irradiated with an HeNe laser caused increases in the fluorescence distribution over time, while no change of distribution was observed in three other conditions (only Zn CP-III added, only HeNe laser irradiation, or non-treated). The result indicates that the photochemical reaction induced by excitation of a photosensitizer, and ROS was derived from the reaction-stimulated monocytes. The activated monocytes generated ROS themselves and H2O2 was visualized by the DCFH fluorescence method. In conclusion, the result clearly shows that activated monocytes are involved in the VSD effect.

Confocal laser scanning microscope (CLSM) is capable of delivering a high axial resolution, and with this instrument even thin layers of cells can be imaged in good quality. Therefore, intracellular uptake and distribution properties of photosensitizer zinc coproporphyrin III tetrasodium salt (Zn CP-III) in human lung small cell carcinoma (Ms-1) were examined by using CLSM. In particular, the uptake of Zn CP-III in cytoplasm, plasma membrane, and nucleus was individually evaluated for the first time from fluorescence images obtained by CLSM. The results show that the Zn CP-III content in three cellular areas correlates with extracellular Zn CP-III concentration and time of incubation with Zn CP-III. Furthermore, it was found that the cytoplasmic fluorescence was approximately two times higher than that in the nucleus under all uptake conditions. In addition, cellular accumulation of Zn CP-III was compared with photodynamic cytotoxicity. The photocytotoxicity was to a great extent dependent on the uptake of the photosensitizer. The damaged site of Ms-1 cells induced by photodynamic therapy was plasma membrane. However, the content of Zn CP-III accumulated in cytoplasm was the highest among the three areas, implying that, besides the direct damage on plasma membrane, an oxidative damage to cellular component arose from the cytoplasmic Zn CP-III may also play an important role in photocytotoxicity. The quantitative information obtained in this study will be useful for further investigation of the photocytotoxicity as well as the uptake mechanism of photosensitizer.

A technique was developed to reconstruct the cross-sectional image of the absorption distribution in a diffuse medium using backscattered light. In this technique, we illuminate an object with an ultra-short pulse, and measure the time-resolved pulse shape of the light backscattered from the object. The absorption distribution of the scattering object can be estimated using the propagation-path distribution of photons at each detection time and the optical impulse response of backscattered light. In a simulation, the effectiveness of this technique was verified in the cases of a layered absorber and a three dimensional absorber. The nonlinear relationship between the depth of the probing region and the propagation time was clarified. The accuracy of the image reconstruction was significantly improved by the aperiodic sampling of the backscattered impulse response according to the nonlinear relation. The feasibility of the proposed technique was verified in the experiment with a model phantom.

When a randomized algorithm elects a leader on anonymous networks, initial information (which is called in general initial condition in this paper) of some sort is always needed. In this paper, we study common properties of initial conditions that enable a randomized algorithm to elect a leader. In the previous papers, the author introduced the notion of transformation between initial conditions using distributed algorithms. By using this notion of transformation, we investigate the property of initial conditions for the leader election. We define that an initial condition C is p(N)-complete if there exists some randomized algorithm that elects a leader with probability p(N) on any size N network satisfying C. We show that we can divide p(N)-completeness into four types as follows. 1. p(N)=1: For any 1-complete initial conditions, there exists a deterministic distributed algorithm that can compute the size of the network for any initial information satisfying the initial condition. 2. inf p(N) >0: For any p(N)-complete initial conditions with inf p(N) >0, there exists a deterministic distributed algorithm that can compute an upper-bound for the size of the network for any initial information satisfying the initial condition. 3. inf p(N) converges to 0: The set of p(N)-complete initial conditions varies depending on the decrease rate of p(N). 4. p(N) decreases exponentially: Any initial condition is regarded as p(N)-complete.

In this paper, we review recent developments in the field of optical regeneration for both ultra long-haul transmission and terrestrial networking applications. Different techniques (2R/3R) using nonlinear properties of materials and/or devices are proposed such as saturable absorber or InP based interferometer structures showing regenerative capabilities. Principles of operation as well as system experiments are described.

Human tissues conduct electricity about as well as semiconductors. However, there are large differences between tissues which have recently been shown to be determined mainly by the structure of the tissue. For example, the impedance spectrum of a layered tissue such as skin is very different to that of the underlying tissues. The way in which the cells are arranged and also the size of the nucleus are both important. Some of the recent developments in measurement and modelling techniques are described and the relationship between tissue structures and impedance spectra is outlined. The illustrations and examples look at the effect of premalignant changes on localised impedance spectra measured from cervical tissues. Electrical Impedance Tomographic measurements on lung tissue are used to show the maturational changes of lung structure in neonates. The conclusion contains some speculation as to what further research outcomes might occur over the next few years.

We have introduced the first electronic cash scheme with unconditional security. That is, even malicious users with unlimited computational ability cannot forge a coin and cannot change user's identity secretly embedded in each coin. While, the spender's anonymity is preserved by our new blind signature scheme based on unconditionally secure signature proposed in [7]. But the anonymity is preserved only computationally under the assumption that Decisional Diffie-Hellman Problem is intractable.

We have focused on the RIO queueing mechanism in statistical bandwidth allocation service, which uses AF-PHB. We have studied the parameterization of RIO to achieve both high throughput and low delay. We were able to parameterize RIO for that purpose in terms of both minth and maxp used in dropping OUT packets. Furthermore, we have also examined the parameterization regarding EWMA (Exponential Weighted Moving Average), i.e., weight factor wqout, and have shown that dropping OUT packets should depend upon the queue length without much delay unlike in RED. From our simulation results, we could see that our parameterization provided high throughput performance and also limited the queue length in a narrow range more effectively.

Technique of Measuring 3-D velocity vector components is important for the correct diagnosis of the blood flow pattern and quantitative assessment of intratumor perfusion. However, present equipment based on ultrasonic Doppler can not provide us true 3-D velocity. To overcome the problem, we previously proposed a new method of 3-D velocity vector measurement. The method uses 2-D array probe and enable us to obtain three components of velocity vector with real time by integrating the Doppler phase shift on the each element with the relative small single aperture compared with conventional method. Basic performance of the method has been evaluated by computer simulation. In this paper, to evaluate the feasibility of the proposed method, experimental investigation using a simple ring array probe and a phantom were carried out. Three components of velocity vector for different velocity magnitude and flow direction were measured. Experimental results validated its ability of measuring 3-D velocity and its feasibility.

The provisioning of QoS in the Internet is gaining an increasing attention, thus the importance of methods capable of estimating the bandwidth requirement of traffic flows is constantly growing. This information can be used for a wide range of purposes. Admission control, QoS routing and load sharing all need the same basic information in order to be able to make decisions. This paper describes a number of methods that can be used to arrive at precise estimates of the bandwidth requirement focusing on those that are based on the theory of large deviations. A methodology is presented that allows the reformulation of earlier solutions based on the estimation of some form of an overflow probability so that their output becomes a bandwidth-type quantity, the format preferred by Internet control applications. The methodology provides two tracks for the conversion: an indirect method that encapsulates the overflow probability-type approach as an embedded calculation and a direct method that immediately results in the estimate of the bandwidth requirement. The paper introduces a novel method for the direct computation of the bandwidth requirement of Internet traffic flows using the many sources asymptotic regime of the large deviation theory. The direct bandwidth estimator method reduces the computational complexity of the calculations, since it results directly in the bandwidth requirement, allowing the omission of the frequent and costly computation of the buffer overflow probability. The savings arising from the reduction in computational complexity are demonstrated in a numerical example.

785 nm (AlGaAs) laser diode (LD) with a window-mirror structure is demonstrated to be a potential candidate as a highly reliable light source of CD-R. The intermixing of a multi-quantum well structure by silicon implantation is used to form the window-mirror structure. Carbon is adopted as an acceptor because of its low thermal diffusion constant in crystals. As a result, the window-mirror-structure 785 nm AlGaAs LDs with ordinary far field patterns suitable for the actual CD-R drives have shown stable single lateral mode operation up to 250 mW. A mirror degradation level is significantly increased by the window-mirror structure. The pulsed operation current at 160 mW, 70 of the carbon doped LD is reduced by about 15% from that of zinc doped one. Highly reliable 160 mW pulsed operation is also realized at 70. This LD believed to be suited for the next generation high-speed (16-24x) CD-R drives necessitating 160 mW class LD.

Breakthroughs in crystal growth and conductivity control of nitride semiconductors during last two decades have led to such developments as high-brightness blue and green light-emitting diodes and long-lived violet laser diodes and so on. All of these nitride-based devices are robust and the most environmentally-friendly ones available. They enable us to save tremendous amount of energy and will be key devices in advanced information technology. Further progress in the area of crystal growth and device engineering will open up new frontier devices based on nitride semiconductors. In this paper, the evolution of nitride-based light-emitting devices is reviewed and the key issues, which must be addressed for nitrides to be fully developed, are discussed.

In recent years, several inverse solutions of magnetoencephalography (MEG) have been proposed. Among them, the multiple signal classification (MUSIC) method utilizes spatio-temporal information obtained from magnetic fields. The conventional MUSIC method is, however, sensitive to Gaussian noise and a sufficiently large signal-to-noise ratio (SNR) is required to estimate the number of sources and to specify the precise locations of electrical neural activities. In this paper, a new algorithm for solving the inverse problem using the fourth order MUSIC (FO-MUSIC) method is proposed. We apply it to the MEG source estimation problem. Numerical simulations demonstrate that the proposed FO-MUSIC algorithm is more robust against Gaussian noise than the conventional MUSIC algorithm.

In a shared buffer packet switch, a good buffer management scheme is needed to reduce the overall packet loss probability and improve the fairness between different users. In this paper, a novel buffer control scheme called partial sharing and partial partitioning (PSPP) is proposed. The PSPP is an adaptive scheme that can be dynamically adjusted to the changing traffic conditions while simple to implement. The key idea of the PSPP is that part of the buffer space, proportional to the number of inactive output ports, is reserved for sharing between inactive output ports. This portion of buffer is called PS buffer. The residual buffer space, called PP buffer, is partitioned and distributed to active output ports equally. From the analysis results, we only need to reserve a small amount of PS buffer space to get good performance for the entire system. Computer simulation shows the PSPP control is very robust and very close to the performance of pushout (PO) buffer management scheme which is a scheme considered as optimal in terms of fairness and total loss ratio while too complicated for implementation.

We investigate the engineering of the impurity bands in photonic crystals (PCs) for realizing high-efficiency wave guiding, all-optical switching and optical delay for ultrashort optical pulses. It is found that quasi-flat impurity bands suitable for the transmission of ultrashort pulses can be achieved by properly controlling the configuration of coupled cavity waveguides (CCWs). At sharp corners, high bending efficiency is obtained over the entire impurity band. All-optical switching can be realized by creating a dynamical band gap at the center of an impurity band. The concentration of electromagnetic wave at defect regions leads to high switching efficiency while the tunable feature of PC defects makes all-optical control possible. It is also revealed that CCWs with quasi-flat impurity bands provide efficient group delay for ultrashort pulses with negligible attenuation and distortion. From the viewpoint of practical fabrication, the effect of disorder on the transmission property of impurity bands is discussed and the criterion for localization transition is determined.

Grouping multiple voice frames into a single IP packet ("frame grouping") is a commonly mentioned approach to saving bandwidth in IP telephony. But little is known as to when, how, and how much frame grouping should be done in Internet environment. This paper explores the feasibility and the methods of frame grouping based on Internet delay measurement. Specifically, we propose an adaptive frame grouping method that minimizes the delay violation while reducing the bandwidth usage by as much as a factor of two under real Internet delay fluctuations. The performance of the method is evaluated as it is used against a single voice stream and then against multiple voice streams.

This paper describes the recent progress made in developing wavelength tunable semiconductor light sources for WDM applications. Wide and quasi-continuous wavelength tunings were investigated for a wavelength-selectable laser and a wavelength tunable distributed Bragg reflector (DBR) laser having a super structure grating (SSG). A wavelength-selectable laser consisting of a DFB laser array, a multi-mode interferometer (MMI), and a semiconductor optical amplifier (SOA) demonstrated a quasi-continuous tuning range of 46.9 nm by using temperature control. A wavelength-tunable DBR laser with SSG exhibited a quasi-continuous tuning range of 62.4 nm by using three tuning current controls. Wavelength stabilization was also demonstrated under the temperature variations of 5.

A highly sensitive optical sampling system has been produced by using sum-frequency generation in a periodically poled lithium niobate crystal. When the relations between crystal length and wavelength bandwidth and SFG conversion efficiency were investigated theoretically and experimentally, a system with a 1.4-mm-long periodically poled lithium niobate crystal was found to have a 22.5-nm wavelength bandwidth and a SFG conversion efficiency ten times that of a similar system with a 3-mm-long KTP crystal. The SNR of the system with the 1.4-mm-long PPLN crystal was about 7 dB higher than that of the system with a 3-mm-long KTP crystal, and a temporal resolution better than 1 ps was obtained by using compressed optical sampling pulses. The eye diagram of a 10-Gbit/s RZ optical signal with a 1-mW peak power could be observed, and the eye diagram of a 160-Gbit/s RZ optical signal could be observed clearly.